Herbal enterosorbent effect in newly diagnosed destructive pulmonary tuberculosis management
Background. The search for pathogenetic therapeutic methods aimed at improving the immune status of a patient with tuberculosis without prescribing of specific immunomodulators is still relevant. This became the basis for the planning our research. Enterosorbents belong to safe preparations with immunomodulatory properties, influencing directly and indirectly the state of systemic immunity due to their detoxification effect. The purpose of the research was to study the effect of phytoenterosorbent on the values of systemic immunity and its effectiveness in the complex treatment of patients with newly diagnosed destructive pulmonary tuberculosis. Materials and methods. A randomized controlled trial involved 125 patients with drug-susceptible forms of tuberculosis with pulmonary destruction and without it and 25 healthy volunteers. The state of the humoral and cellular components of immune system, neutrophil and monocytic phagocytosis were studied. Besides the enterosorbent effect on the blood concentration of anti-tuberculosis drug isoniazid in patients was studied. Results. Use of herbal enterosorbent in complex therapy in patients with newly diagnosed destructive pulmonary tuberculosis did not affect the values of cellular immunity, but contributed to the normalization of its B-cell indices: a significant decrease in the number of CD22+ lymphocytes, IgG, IgA levels and circulating immune complexes in patient’s blood, normalization of phagocytic activity of phagocytic cells. The use of herbal enterosorbent in the complex treatment of tuberculosis patients did not lead to a decrease in the blood concentration of anti-tuberculosis drug іsoniazid in the patients, but rather increased it and did not contribute to the deterioration of adverse reactions due to isoniazid. Conclusions. Complex treatment of patients with newly diagnosed destructive pulmonary tuberculosis with the use of herbal enterosorbent resulted in leveraged treatment effectiveness by the rate of cavern healing by 21.4 %.
Full Text:PDF (Русский)
Chernushenko ЕF, Petrenko VM, Panasyukova OR, Tsyigankova LM; et al. Variants of immune system disorders in patients with progressive tuberculosis and non-effective antibacterial therapy. Allergologiya i Immunologiya. 2000;1:99-103. (In Russian).
Salina TYu, Hudzik LB. [Immunopathogenetic mechanisms during tuberculosis infection]. Problemy tuberkuleza i bolezney legkih.2001;8:32-4. (In Russian).
Starostenko SV, Selitskaya RP, Salpagarov AM, et al. Substantiation of the differential use of nonspecific pathogenetic agents in the complex treatment of patients with pulmonary tuberculosis. Pulmonologiya. 2001;1:65-73. (In Russian).
Zabolotnyih NV, Vinogradova TI, Vasileva SN, et al. The activating action of Bestim on the state of macrophages in experimental tuberculosis of varying severity. Problemy tuberkuleza i bolezney legkih. 2003;10:53-6. (In Russian).
Petrenko VM, Cherenko SO, Litvinenko NA, Pogrebna MV, et al. Treatment and long-term results in patients with first diagnosed multiresistant destructive lung tuberculosis. Ukrainskii khimioterapevticheskii zhurnal. 2005;3-4(21):9-13. (In Ukrainian).
Averchenkov VM, Lomachenkov VD, Fedotova NI, Meshkova RYa. Secondary immune deficiency and its correction with myelopid in patients with infiltrative and disseminated tuberculosis. Problemy tuberkuleza i bolezney legkih. 1998;2:20-5. (In Russian).
Kovalchuk LV, Cheredeev AN. New immunopathogenetic views: apoptotic immunodeficiencies. Immunologiya. 1998;6:177-8. (In Russian).
Chernushenko EF, Panasyukova OR, Ilinskaya IF, et al. Disturbances in the regulation of apoptosis of immunocompetent cells in diseases of the lungs. Allergologiya i immunologiya. 2003;4(2):88. (In Russian).
Chernushenko EF. Diagnosis of immune system disorders and immunocorrection principles for lung diseases. Ukraїns'kij zhurnal gematologіi ta transfuzіologіi. 2002;5:40. (In Russian).
Bilyinskiy BT, Serkova VK, Malenkiy VP, Chuiko NA. Effektivnost enterosorbtsii siliksom pri endotoksikozah razlichno' etiologii [Effectiveness of enterosoculation with silicom with endotoxicosis is different in etiology]. In: Meditsinskaya himiya i klinicheskoe primenenie dioksida kremniya [Medical chemistry and clinical application of silicon dioxide]. Kyiv: Naukova dumka; 2003. 417 p. (In Russian).
Raznatovskaia EN, Khlystun VN, Hritsova NA,Voitiuk IM, Pavlovskyi GA. Treatment Success in Patients with Drug-Resistant Pulmonary Tuberculosis in Cavitation of S6 of Lungs and Concomitant Endobronchial Pathology Using Isoniazid-Hydroxymethylquinoxalinedioxyde in the Comprehensive Treatment. Aktual'naia infektologiia. 2015;9(4):55-8. (In Russian). doi: 10.22141/2312-413x.4.09.2015.78831.
Copyright (c) 2017 ACTUAL INFECTOLOGY
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2020