Viral hepatitis in women of reproductive age
Annually in Ukraine, about 17 thousands of newborns are at risk of vertical infection with hepatitis B and C. Identification of infected women at the stage of family planning is the best way to prevent infection in newborns, and therefore it must be performed strictly in accordance with established norms. In case of detection of hepatitis, further tactics depend on the variant of the virus: in case of hepatitis C, pre-pregnancy treatment is preferable. In case of hepatitis B — pregnancy with subsequent simultaneous vaccination of the newborn. Antiviral therapy is possible in women with high viral load to prevent intrauterine infection. Similar tactics should be followed in case of in vitro fertilisation too. The text of the lecture is illustrated by clinical examples. The lecture is intended for infectious disease physicians and obstetrician-gynecologists.
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Gural' AL, Marevskii VF, Sergeeva TA. Epidemiological aspects of hepatitis B and C in Ukraine. Zbіrnik naukovikh prats' spіvrobіtnikіv KMAPO іm. P. L. Shupika. 2000;9(4):56-60.
Tosone G, Maraolo AE, Mascolo S, Palmiero G, Tambaro O, Orlando R. Vertical hepatitis C virus transmission: Main questions and answers.World J Hepatol. 2014 Aug 27;6(8):538-48. doi: 10.4254/wjh.v6.i8.538.
European Paediatric Hepatitis C Virus Network. A significant sex — but not elective cesarean section — effect on mother-to child transmission of hepatitis C virus infection. J Infect Dis. 2005;192:1872-9. doi: 10.1086/497695.
Han GR, Cao MK, Zhao W, et al. A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection. J Hepatol. 2011 Dec;55(6):1215-21. doi: 10.1016/j.jhep.2011.02.032.
Ghamar Chehreh ME, Tabatabaei SV, Khazanehdari S, Alavian SM. Effect of cesarean section on the risk of perinatal transmission of hepatitis C virus from HCV-RNA+/HIVmothers: a meta-analysis. Arch Gynecol Obstet. 2011 Feb;283(2):255-60. doi: 10.1007/s00404-010-1588-9.
Centers for Disease Control and Prevention. Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease. Morbidity And Mortality Weekly Report. 1998;47(RR19):1-39.
American College of Obstetricians and Gynecologists. ACOG educational bulletin. Viral hepatitis in pregnancy. Number 248, July 1998 (replaces No. 174, November 1992). Int J Gynaecol Obstet. 1998;63(2):195-202.
Recommendations for reducing the risk of viral transmission during fertility treatment with the use of autologous gametes: a committee opinion. Fertility and Sterility. 2013;99(2):340-6. doi:10.1016/j.fertnstert.2012.08.028.
Oger P, Yazbeck C, Gervais A, et al. Adverse effects of hepatitis B virus on sperm motility and fertilization ability during IVF. Reprod Biomed Online. 2011 Aug;23(2):207-12. doi: 10.1016/j.rbmo.2011.04.008.
Garrido N, Gil-Salom M, Martínez-Jabaloyas JM, Meseguer M. First report of the absence of viral load in testicular sperm samples obtained from men with hepatitis C and HIV after washing and their subsequent use. FertilSteril. 2009 Sep;92(3):1012-5. doi: 10.1016/j.fertnstert.2009.01.159.
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