Antibiotic susceptibility and antibiotic resistance according to the data of Kyiv Municipal Children’s Clinical Infectious Diseases Hospital from 2012 to 2016

O.V. Vygovska, E.A. Grechuha, O.I. Tkachuk

Abstract


The state of antibiotic susceptibility of bacterial infectious agents was analyzed in the period from 2012 to 2016 in 498 patients. The bulk — children aged 0 months to 18 years. The main material for the study was a smear from the pharynx (41 %), feces (17 %), a nasal swab (13 %), urine (10 %). The main pathogens were identified: Staphylococcus aureus (66 %), Streptococcus pneumoniae (1 %), Klebsiella pneumoniae (5 %), Streptococcus pyogenes (15 %). The antibiotic susceptibility of S.aureus to antibacterial agents of the cephalosporin group, fluoroquinolones, carbopenems; Str.pyogenes — to the antibacterial agents of the cephalosporin group has been detected in biological isolates of specimens from children with various infectious pathologies.

Keywords


antibiotic resistance; antibiotic susceptibility; infectious diseases; bacteria; researches; Staphylococcus aureus; Streptococcus pyogenes; Klebsiella pneumoniae

References


Sir Alexander Fleming's speech at the Nobel Banquet in Stockholm, December 10, 1945. Available from: https://www.nobelprize.org/nobel_prizes/medicine/laureates/1945/fleming-speech.html .

Institute of Medicine (US) Committee on Emerging Microbial Threats to Health, author. Lederbreg J, Shope LE, Oaks SC Jr, editors. Emerging Infections: Microbial Threats to Health in the United States. Washington (DC): National Academies Press (US); 1992. doi:10.17226/2008.

Golkar Z, Bagasra O, Pace DG. Bacteriophage therapy: a potential solution for the antibiotic resistance crisis. J Infect Dev Ctries. 2014 Feb 13;8(2):129-36. doi: 10.3855/jidc.3573.

Gould IM, Bal AM. New antibiotic agents in the pipeline and how they can overcome microbial resistance. Virulence. 2013 Feb 15;4(2):185-191.doi: 10.4161/viru.22507.

Wright GD. Something old, something new: revisiting natural products in antibiotic drug discovery. Can J Microbiol. 2014 Mar;60(3):147-54. doi: 10.1139/cjm-2014-0063.

Sengupta S, Chattopadhyay MK, Grossart HP. The multifaceted roles of antibiotics and antibiotic resistance in nature. Front Microbiol. 2013 Mar 12;4:47. doi: 10.3389/fmicb.2013.00047.

Centers for Disease Control and Prevention. 2013 Threat Report. Antibiotic resistance threats in the United States. Atlanta, USA: CDC; 2013. 144 p.

Shrestha LB. Life Expectancy in the United States: CRS Report for Congress. Available from: http://www.menshealthnetwork.org/Library/CRSlifeexpectRL32792.pdf. Accessed: August 16, 2006.

Barber M, Rozwadowska-dowzenko M. Infection by penicillin resistant Staphylococci. Lancet. 1948 Oct 23;2(6530):641-4. PMID: 18890505.

Dern GV, Heilmann KP, Huynh HK, Rhomberg PR, Coffman SL, Brueggemann AB. Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000, including a comparison of resistance rates since 1994-1995. Antimicrob Agents Chemother. 2001 Jun;45(6):1721-9. doi: 10.1128/AAC.45.6.1721-1729.2001.

World Health Organization. Antimicrobial resistance: global report on surveillance 2014. Geneva, Switzerland: WHO Press; 2014. 257 p.

Czaplewski L, Bax R, Clokie M, et al. Alternatives to antibiotics-a pipeline portfolio review. Lancet Infect Dis. 2016 Feb;16(2):239-51. doi: 10.1016/S1473-3099(15)00466-1.

McFarland J. The nephelometer: an instrument for estimating the number of bacteria in suspensions used for calculating the opsonic index and for vaccines. JAMA. 1907;XLIX(14):1176-1178. doi:10.1001/jama.1907.25320140022001f.

Baron S, editor. Medical Microbiology, 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. PMID: 21413252.

Jorgensen JH, Ferraro MJ. Antimicrobial susceptibility testing: a review of general principles and contemporary practices. Clin Infect Dis. 2009 Dec 1;49(11):1749-55. doi: 10.1086/647952.

Ministry of health of Ukraine. Ministry of education of Ukraine. Order № 167 dated April 05, 2007. On the approval of methodological guidelines "Determination of the sensitivity of microorganisms to antibacterial drugs”. Available from: http://mozdocs.kiev.ua/view.php?id=6958. Accessed: April 05, 2007. (in Ukrainian).

Barton MD. Antibiotic use in animals feed and its impact on human health. Nutr Res Rev. 2000 Dec;13(2):279-99. doi: 10.1079/095442200108729106.

Kiivet RA, Bíba V, Enache D, et al. Changes in the use of antibacterial drugs in the countries of Central and Eastern Europe. Eur J Clin Pharmacol. 1995;48(3-4):299-304. PMID: 7589059.

Samarin DV. Antibiotic resistance. Therapia. 2009;12(42):43-45. (in Russian).

Rossolini GM, Arena F, Pecile P, Pollini S. Update on the antibiotic resistance crisis. Curr Opin Pharmacol. 2014 Oct;18:56-60. doi: 10.1016/j.coph.2014.09.006.

Netsvyetayeva I, Fraczek M, Piskorska K, et al. Staphylococcus aureus nasal carriage in Ukraine: antibacterial resistance and virulence factor encoding genes. BMC Infect Dis. 2014 Mar 5;14:128. doi: 10.1186/1471-2334-14-128.




DOI: https://doi.org/10.22141/2312-413x.5.5.2017.121632

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 ACTUAL INFECTOLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта