The state of antibiotic susceptibility of bacterial infectious agents was analyzed in the period from 2012 to 2016 in 498 patients. The bulk — children aged 0 months to 18 years. The main material for the study was a smear from the pharynx (41 %), feces (17 %), a nasal swab (13 %), urine (10 %). The main pathogens were identified: Staphylococcus aureus (66 %), Streptococcus pneumoniae (1 %), Klebsiella pneumoniae (5 %), Streptococcus pyogenes (15 %). The antibiotic susceptibility of S.aureus to antibacterial agents of the cephalosporin group, fluoroquinolones, carbopenems; Str.pyogenes — to the antibacterial agents of the cephalosporin group has been detected in biological isolates of specimens from children with various infectious pathologies.
antibiotic resistance; antibiotic susceptibility; infectious diseases; bacteria; researches; Staphylococcus aureus; Streptococcus pyogenes; Klebsiella pneumoniae
Sir Alexander Fleming's speech at the Nobel Banquet in Stockholm, December 10, 1945. Available from: https://www.nobelprize.org/nobel_prizes/medicine/laureates/1945/fleming-speech.html .
Institute of Medicine (US) Committee on Emerging Microbial Threats to Health, author. Lederbreg J, Shope LE, Oaks SC Jr, editors. Emerging Infections: Microbial Threats to Health in the United States. Washington (DC): National Academies Press (US); 1992. doi:10.17226/2008.
Golkar Z, Bagasra O, Pace DG. Bacteriophage therapy: a potential solution for the antibiotic resistance crisis. J Infect Dev Ctries. 2014 Feb 13;8(2):129-36. doi: 10.3855/jidc.3573.
Gould IM, Bal AM. New antibiotic agents in the pipeline and how they can overcome microbial resistance. Virulence. 2013 Feb 15;4(2):185-191.doi: 10.4161/viru.22507.
Wright GD. Something old, something new: revisiting natural products in antibiotic drug discovery. Can J Microbiol. 2014 Mar;60(3):147-54. doi: 10.1139/cjm-2014-0063.
Sengupta S, Chattopadhyay MK, Grossart HP. The multifaceted roles of antibiotics and antibiotic resistance in nature. Front Microbiol. 2013 Mar 12;4:47. doi: 10.3389/fmicb.2013.00047.
Centers for Disease Control and Prevention. 2013 Threat Report. Antibiotic resistance threats in the United States. Atlanta, USA: CDC; 2013. 144 p.
Shrestha LB. Life Expectancy in the United States: CRS Report for Congress. Available from: http://www.menshealthnetwork.org/Library/CRSlifeexpectRL32792.pdf. Accessed: August 16, 2006.
Barber M, Rozwadowska-dowzenko M. Infection by penicillin resistant Staphylococci. Lancet. 1948 Oct 23;2(6530):641-4. PMID: 18890505.
Dern GV, Heilmann KP, Huynh HK, Rhomberg PR, Coffman SL, Brueggemann AB. Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000, including a comparison of resistance rates since 1994-1995. Antimicrob Agents Chemother. 2001 Jun;45(6):1721-9. doi: 10.1128/AAC.45.6.1721-1729.2001.
World Health Organization. Antimicrobial resistance: global report on surveillance 2014. Geneva, Switzerland: WHO Press; 2014. 257 p.
Czaplewski L, Bax R, Clokie M, et al. Alternatives to antibiotics-a pipeline portfolio review. Lancet Infect Dis. 2016 Feb;16(2):239-51. doi: 10.1016/S1473-3099(15)00466-1.
McFarland J. The nephelometer: an instrument for estimating the number of bacteria in suspensions used for calculating the opsonic index and for vaccines. JAMA. 1907;XLIX(14):1176-1178. doi:10.1001/jama.1907.25320140022001f.
Baron S, editor. Medical Microbiology, 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. PMID: 21413252.
Jorgensen JH, Ferraro MJ. Antimicrobial susceptibility testing: a review of general principles and contemporary practices. Clin Infect Dis. 2009 Dec 1;49(11):1749-55. doi: 10.1086/647952.
Ministry of health of Ukraine. Ministry of education of Ukraine. Order № 167 dated April 05, 2007. On the approval of methodological guidelines "Determination of the sensitivity of microorganisms to antibacterial drugs”. Available from: http://mozdocs.kiev.ua/view.php?id=6958. Accessed: April 05, 2007. (in Ukrainian).
Barton MD. Antibiotic use in animals feed and its impact on human health. Nutr Res Rev. 2000 Dec;13(2):279-99. doi: 10.1079/095442200108729106.
Kiivet RA, Bíba V, Enache D, et al. Changes in the use of antibacterial drugs in the countries of Central and Eastern Europe. Eur J Clin Pharmacol. 1995;48(3-4):299-304. PMID: 7589059.
Samarin DV. Antibiotic resistance. Therapia. 2009;12(42):43-45. (in Russian).
Rossolini GM, Arena F, Pecile P, Pollini S. Update on the antibiotic resistance crisis. Curr Opin Pharmacol. 2014 Oct;18:56-60. doi: 10.1016/j.coph.2014.09.006.
Netsvyetayeva I, Fraczek M, Piskorska K, et al. Staphylococcus aureus nasal carriage in Ukraine: antibacterial resistance and virulence factor encoding genes. BMC Infect Dis. 2014 Mar 5;14:128. doi: 10.1186/1471-2334-14-128.