Effect of sodium selenite on thyroid gland functioning and efficacy of chemotherapy in tuberculosis patients with a concomitant diabetes mellitus and autoimmune thyroiditis

S.L. Matveyeva, N.N. Tyazhlova, K.V. Yakovleva, S.O. Matveyev

Abstract


In 40 tuberculosis patients with diabetes mellitus and autoimmune thyroiditis ultrasonic research of thyroid structure and measurement of levels of free thyroxine, thyroid stimulating hormone, antibodies to thyroglobulin and peroxidase and selenium in the serum of blood were conducted by immune-enzyme method at the beginning and at the end of the phase of intensive chemotherapy depending on the prescribing of sodium selenite. Efficacy of antituberculosis chemotherapy was estimated by general clinical, bacteriological and X-ray criteria. Autoimmune thyroiditis with the phenomena of subclinical hypothyroidism is diagnosed for all investigational persons. Prescribing of sodium selenite during the phase of intensive chemotherapy promotes the recovery of thyroid function. Rates of intoxication symptoms elimination, abacillation reduction and healing of the cavities at the end of intensive phase of chemotherapy were for certain higher in the group of patients with prescribing of sodium selenite.

Keywords


pulmonary tuberculosis; diabetes mellitus; autoimmune thyroiditis

References


Kaminskaya GO, Abdullaev RYu. Pathophysiological prerequisites for the negative impact of diabetes mellitus on the course of pulmonary tuberculosis. Tuberculosis and Lung Diseases. 2014;91(3):5-10. (in Russian).

Matveyeva SL. The role of premorbid thyroid status in forming cellular immunity and outputs of chemotherapy in patients with destructive tuberculosis of lungs. Problemi endokrinnoi patologii. 2011;3:35-43. (in Russian).

Matveyeva SL. Influence of thyroid function activity on the indexes of immunity in tuberculosis patients. Tuberculosis, Lung Diseases, HIV Infection. 2016;2(25):40-43. (in Russian).

Matveyeva SL. Clinical characteristics and chemotherapy response in pulmonary tuberculosis patients with thyroid pathology. Tuberculosis, Lung Diseases, HIV Infection. 2011;2(05):39-44. (in Russian).

Cherenco SA , Matveyeva SL. Correlation between clinical course of pulmonary tuberculosis, thyroid gland function and some cytokines. Ukrainian Pulmonology Journal. 2011;2:35-38. (in Russain).

Yuzvenko TYu. Incidence of Thyroid Structural Disorders in Patients with Type 2 Diabetes Mellitus. Mezhdunarodnyi Endokrinologicheskii Zhurnal . 2015;1(65):19-22. (in Ukrainian).

Baker MA, Harries AD, Jeon CY, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med. 2011 Jul 1;9:81. doi: 10.1186/1741-7015-9-81.

Dora JM, Machado WE, Rheinheimer J, Crispim D, Maia AL. Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case–control study and meta-analysis. Eur J Endocrinol. 2010 Sep;163(3):427-34. doi: 10.1530/EJE-10-0419.

Duntas L.H. The role of iodine and selenium in autoimmune thyroiditis. Horm Metab Res. 2015 Sep;47(10):721-6. doi: 10.1055/s-0035-1559631.

Вrigelius -Flohѐ R. The evolving versatility of selenium in biology. Antioxid Redox Signal. 2015 Oct 1;23(10):757-60. doi: 10.1089/ars.2015.6469.

Faurholt-Jepsen D, Range N, Praygod G, et al. The role of diabetes co-morbidity for tuberculosis treatment outcomes: A prospective cohort study from Mwanza, Tanzania. BMC Infect Dis. 2012 Jul 27;12:165. doi: 10.1186/1471-2334-12-165.

Faurholt-Jepsen D, Range N, Praygod G, et al. The role of diabetes on the clinical manifestations of pulmonary tuberculosis. Trop Med Int Health. 2012 Jul;17(7):877-83. doi: 10.1111/j.1365-3156.2012.03002.x.

Hage M, Zantout MS, Azar ST. Thyroid Disorders and Diabetes Mellitus. J Thyroid Res. 2011;2011: 439463. doi: 10.4061/2011/439463.

Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. Int J Clin Pract. 2010 Jul;64(8):1130-9. doi: 10.1111/j.1742-1241.2010.02376.x.

Ramasamy V, Kadiyala R, Fayyaz F, Mallipedhi A, Baglioni P, Okosieme OE. Value of a baseline serum thyrotropin as a predictor of hypothyroidism in patients with diabetes mellitus. Endocr Pract. 2011 Jan-Feb;17(1):26-32. doi: 10.4158/EP10096.OR.

Tomer Y, Menconi F. Type 1 diabetes and autoimmune thyroiditis: the genetic connection. Thyroid. 2009 Feb; 19(2):99-102. doi: 10.1089/thy.2008.1565.




DOI: https://doi.org/10.22141/2312-413x.5.5.2017.121639

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 ACTUAL INFECTOLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта