Clinical features of nervous system disorders in patients with EBV as monoinfection and in association with other herpes viruses in their reactivation and persistence

A.O. Rudenko, L.V. Muravska, P.A. Dyachenko, B.A. Parkhomets, V.Yu. Klyus


We have examined 48 patients with nervous system disorders caused by Epstein — Barr virus (EBV) as monoinfection or in association with other herpes viruses during their reactivation (n = 34) or persistence (n = 14). With the activation of Epstein — Barr virus infection, arachnoiditis is most often diagnosed — 29.4 %, as well as arachnoencephalitis — 26.5 %, rarely — disseminated encephalomyelitis (DEM) — 11.8 % and encephalitis 11.8 %, encephalopolyneuropathy — 5.9 %, meningoencephalitis — 5.9 %. With persistence of herpes viruses, encephalitis was not detected, arachnoiditis was diagnosed in 28.6 % of patients, arachnoencephalitis — in 28.6 %, and DEM — in 14.3 %. Differences in the detection of neurologic symptoms and syndromes in the group of patients with activation and reactivation are shown as compared with persistence.


Epstein — Barr virus; reactivation; persistence; nervous system disorders; clinical syndromes


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