Status of antiviral immunity in patients with non-alcoholic liver fatty disease, who were Chornobyl NPP accident liquidators

A.A. Chumak, O.V. Nosach, E.O. Sarkisova, O.V. Gasanova, L.M. Ovsyannikova, O.Ya. Pleskach, S.M. Alokhina, V.I. Shynkarenko, T.I. Shyiko


34 men were examined, who after participating in the liquidation of the Chornobyl NPP accident developed non-alcoholic fatty liver disease. The state of antiviral defense was evaluated by the levels of immunoglobulin (Ig) G and IgM antibodies in the blood serum. In most patients with non-alcoholic steatohepatitis, who were Chornobyl NPP accident liquidators, antibodies of the IgG, but not IgM class to the persistent mixed infection with herpes simplex virus types 1 and 2, cytomegaly and Epstein-Barr were found. A positive correlation was established between the antibody titers to the herpes simplex virus types 1 and 2 (anti-HSV-1/2 IgG) and cytomegalovirus (anti-CMV IgG) (rs = 0.383, p = 0.040), as well as between the antibodies titers to the nuclear antigen of Epstein-Barr virus (anti-EBV NA IgG) and antibodies to core antigen of Epstein-Barr (anti-EBV VCA IgG) (rs = 0.584, p = 0.002) in patients with persistent mixed infection of these herpesviruses.


Herpesviridae family viruses; non-alcoholic fatty liver disease; Chornobyl NPP accident liquidators


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