Using Hippophae rhamnoides leaf extract in the treatment of chicken pox in children


  • S.O. Кramarov Bogomolets National Medical University, Kyiv, Ukraine,
  • V.V. Yevtushenko Bogomolets National Medical University, Kyiv, Ukraine,
  • V.O. Shadrin Bogomolets National Medical University, Kyiv, Ukraine,
  • E.V. Golovach Kyiv Children’s Clinical Infectious Diseases Hospital, Kyiv, Ukraine,
  • Т.M. Kaminskaya Kyiv Children’s Clinical Infectious Diseases Hospital, Kyiv, Ukraine,



chicken pox, children, Hippophae rhamnoides extract


Background. In Ukraine, about 150 thousand children suffer from chicken pox every year. Symptomatic and supportive treatment is indicated for all forms of chicken pox. The purpose of the study was to evaluate the efficacy and tolerability of Hippophae rhamnoides (Erebra) extract in the comprehensive treatment of chicken pox in children. Materials and methods. Research design: prospective, open-label, controlled. The study involved children who underwent inpatient treatment with a diagnosis of chicken pox during 2017–2018. Patients in the main group received Hippophae rhamnoides extract in the combined treatment of chicken pox, standard symptomatic therapy was prescribed to control patients. Results. Sixty four children were examined, the main group consisted of 34 patients, control group — 30 individuals. On the background of therapy, a positive dynamics of clinical symptoms was observed in all patients. On day 5, fever was more frequently detected in controls than in the main group (50.0 vs 23.5 %, p < 0.05 according to the χ2 criterion). Disorders of the general state on day 3 of observation were noted in 55.8 % of children in the main group and in 86.7 % of controls (p < 0.05 according to χ2 criterion). Conclusions. The use of Hippophae rhamnoides extract in comprehensive therapy of children with chicken pox accelerates the norma­lization of clinical symptoms. The Hippophae rhamnoides extract has a high safety profile and is well tolerated.


Nezgoda II, Levytska LI. Chickenpox in children. Infekcijni hvoroby. 2017;(87):61-70. doi: 10.11603/1681-2727.2017.1.7786.

English R. Varicella. Pediatr Rev. 2003 Nov;24(11):372-9.

National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. Chickenpox (Varicella). Available from: Accessed: July 1, 2016.

RxList. Valtrex (Valacyclovir Hydrochloride): Side Effects, Interactions, Warning, Dosage and Uses. Available from: Accessed: April 16, 2018.

Mikaeloff Y, Kezouh A, Suissa S. Nonsteroidal anti-inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease. Br J Clin Pharmacol. 2008 Feb;65(2):203-9. doi: 10.1111/j.1365-2125.2007.02997.x.

Church DS, Church MK. Pharmacology of Antihistamines. World Allergy Organ J. 2011 Mar;4(3 Suppl):S22-7. doi: 10.1097/WOX.0b013e3181f385d9.

Erebra: instructions for medical use of the drug. Compendium Drugs. 2017. Available from: Accessed: April 16, 2018.

Suomela JP, Ahotupa M, Yang B, Vasankari T, Kallio H. Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. J Agric Food Chem. 2006 Sep 20;54(19):7364-9. doi: 10.1021/jf061889r.

Jain M, Ganju L, Katiyal A, et al. Effect of Hippophae rhamnoides leaf extract against Dengue virus infection in human blood-derived macrophages. Phytomedicine. 2008 Oct;15(10):793-9. doi: 10.1016/j.phymed.2008.04.017.

Ganju L, Padwad Y, Singh R, et al. Anti-inflammatory activity of Seabuckthorn (Hippophae rhamnoides) leaves. Int Immunopharmacol. 2005 Nov;5(12):1675-84. doi: 10.1016/j.intimp.2005.03.017.

Geetha S, Sai Ram M, Singh V, Ilavazhagan G, Sawhney RC. Anti-oxidant and immunomodulatory properties of seabuckthorn (Hippophae rhamnoides) - an in vitro study. J Ethnopharmacol. 2002 Mar;79(3):373-8.

Larmo P, Alin J, Salminen E, Kallio H, Tahvonen R. Effects of sea buckthorn berries on infections and inflammation: a double-blind, randomized, placebo-controlled trial. Eur J Clin Nutr. 2008 Sep;62(9):1123-30. doi: 10.1038/sj.ejcn.1602831.

Torelli A, Gianchecchi E, Piccirella S, et al. Sea buckthorn bud extract displays activity against cell-cultured Influenza virus. J Prev Med Hyg. 2015 Aug 5;56(2):E51-6.

Enkhtaivan G, Maria JK, Pandurangan M, Hur J, Leutou A, Kim D. Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts. Saudi Journal of Biological Sciences. 2017;24(7):1646-1656. doi: 10.1016/j.sjbs.2016.01.004.

Shipulina LD, Tolkachev ON, Krepkova LV, Bortnikova VV, Shkarenkov AA. Anti-viral, anti-microbial and toxicological studies on Seabuckthorn (Hippophae rhamnoides). In: Singh V, editor. Seabuckthorn (Hippophae L.): A Multipurpose Wonder Plant, Volume 2: Biochemistry and pharmacology. New Delhi, India: Indus Publishing Company; 2003. 471-483 pp.

Kwon EY, Lee J, Kim YJ, et al. Seabuckthorn Leaves Extract and Flavonoid Glycosides Extract from Seabuckthorn Leaves Ameliorates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obesity. Nutrients. 2017 Jun 2;9(6). pii: E569. doi: 10.3390/nu9060569.

Padwad Y, Ganju L, Jain M, et al. Effect of leaf extract of Seabuckthorn on lipopolysaccharide induced inflammatory response in murine macrophages. Int Immunopharmacol. 2006 Jan;6(1):46-52. doi: 10.1016/j.intimp.2005.07.015.

Tanwar H, Shweta, Singh D, Singh SB, Ganju L. Anti-inflammatory activity of the functional groups present in Hippophae rhamnoides (Seabuckthorn) leaf extract. Inflammopharmacology. 2018 Feb;26(1):291-301. doi: 10.1007/s10787-017-0345-0.

Jayashankar B1, Mishra KP, Kumar MS, et al. A supercritical CO₂ extract from seabuckthorn leaves inhibits pro-inflammatory mediators via inhibition of mitogen activated protein kinase p38 and transcription factor nuclear factor-κB. Int Immunopharmacol. 2012 Aug;13(4):461-7. doi: 10.1016/j.intimp.2012.05.011.

Jayashankar B1, Singh D1, Tanwar H, et al. Augmentation of humoral and cellular immunity in response to Tetanus and Diphtheria toxoids by supercritical carbon dioxide extracts of Hippophae rhamnoides L. leaves. Int Immunopharmacol. 2017 Mar;44:123-136. doi: 10.1016/j.intimp.2017.01.012.

Wani TA, Wani SM, Ahmad M, et al. Bioactive profile, health benefits and safety evaluation of sea buckthorn (Hippophae rhamnoides L.): A review. ," Cogent Food and Agriculture. 2016;2(1):1128519. doi: 10.1080/23311932.2015.1128519.

Zakynthinos G, Varzakas T. Hippophae rhamnoides: safety and nutrition. Curr Res Nutr Food Sci 2015;3(2):89-97. doi: 10.12944/CRNFSJ.3.2.01.

Agarwal MJ, Chanda S, Rao ME, Ganju L. Effect of Hippophae Rhamnoides Leaf Extract against Dengue Virus Infection in U937 Cells. Virol-mycol. 2016;5:157. doi:10.4172/2161-0517.1000157.



Original Researches