Atypical forms of acute Epstein-Barr virus infection in children
Keywords:Epstein-Barr virus infection, atypical form, children
AbstractBackground. Today, there is a tendency to increase in Epstein-Barr virus infection (EBVI) morbidity. The purpose of the study was to identify the incidence and features of atypical forms of acute EBVI in children. Material and methods. We have examined 28 children aged 6 months to 18 years with EBVI who were monitored in pediatric polyclinic. The activity of alanine aminotransferase and aspartate aminotransferase, levels of bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, markers of viral hepatitis were evaluated. Enzyme-linked immunosorbent assay was performed with determination of blood markers of EBV (immunoglobulin (Ig) M viral capsid antigen (VCA), IgG early antigen, IgG VCA, avidity) and cytomegalovirus (CMV) (IgM, IgG, avidity), EBV deoxyribonucleic acid (DNA), CMV DNA; polymerase chain reaction was used for serological diagnosis. The data were processed by statistical analysis using Statistica 6 program. Results. In 71.4 % of cases, EBVI had usual course and moderate severity. The atypical forms of acute EBVI were observed in 28.5 % of cases. Clinically atypical forms began mainly from signs of acute respiratory infections followed by lesions of the internal organs (liver and heart), in particular, in children under 1 year of age, and changes in liver functional tests. Conclusions. The incidence of atypical forms of EBVI is 28.5 %. Atypical forms of EBVI are more common in infants and adolescents and associated with the damage to the internal organs (liver and heart).
Lavrentyeva IN, Finogenova NA, Mamedova EA, et al. Peculiarities of diagnosis and clinical course of herpes infections caused by Epstein-Barr virus and human herpes virus type 6 at neutropenia in infants. Detskie Infekcii. 2011;10(3):11-15. (in Russian).
Allen UD, Preiksaitis JK; AST Infectious Diseases Community of Practice. Epstein-Barr virus and posttransplant lymphoproliferative disorder in solid organ transplantation. Am J Transplant. 2013 Mar;13(Suppl 4):107-120. doi: 10.1111/ajt.12104.
Sanosyan A, Rutagwera DG, Molès J-P, et al. Increased Epstein–Barr virus in breast milk occurs with subclinical mastitis and HIV shedding. Medicine (Baltimore). 2016 Jul;95(27):e4005. doi: 10.1097/MD.0000000000004005.
Gao LW, Xie ZD, Liu YY, Wang Y, Shen KL. Epidemiologic and clinical characteristics of infectious mononucleosis associated with Epstein-Barr virus infection in children in Beijing, China. World J Pediatr. 2011 Feb;7(1):45-9. doi: 10.1007/s12519-011-0244-1.
Crowley A, Connell J, Schaffer K, Hall W, Hassan J. Is there diagnostic value in detection of immunoglobulin g antibodies to the epstein-barr virus early antigen? Biores Open Access. 2012 Dec;1(6):291-6. doi: 10.1089/biores.2012.0274.
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