Atypical forms of acute Epstein-Barr virus infection in children


  • T.V. Sorokman State Higher Education Institution of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine
  • N.А. Popelyuk State Higher Education Institution of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine
  • L.V. Shvygar Municipal Children’s Polyclinic, Chernivtsi, Ukraine



Epstein-Barr virus infection, atypical form, children


Background. Today, there is a tendency to increase in Epstein-Barr virus infection (EBVI) morbidity. The purpose of the study was to identify the incidence and features of atypical forms of acute EBVI in children. Material and methods. We have examined 28 children aged 6 months to 18 years with EBVI who were monitored in pediatric polyclinic. The activity of alanine aminotransferase and aspartate aminotransferase, levels of bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, markers of viral hepatitis were evaluated. Enzyme-linked immunosorbent assay was performed with determination of blood markers of EBV (immunoglobulin (Ig) M viral capsid antigen (VCA), IgG early antigen, IgG VCA, avidity) and cytomegalovirus (CMV) (IgM, IgG, avidity), EBV deoxyribonucleic acid (DNA), CMV DNA; polymerase chain reaction was used for serological diagnosis. The data were processed by statistical analysis using Statistica 6 program. Results. In 71.4 % of cases, EBVI had usual course and moderate severity. The atypical forms of acute EBVI were observed in 28.5 % of cases. Clinically atypical forms began mainly from signs of acute respiratory infections followed by lesions of the internal organs (liver and heart), in particular, in children under 1 year of age, and changes in liver functional tests. Conclusions. The incidence of atypical forms of EBVI is 28.5 %. Atypical forms of EBVI are more common in infants and adolescents and associated with the damage to the internal organs (liver and heart).


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Original Researches