Attention: intestinal yersiniosis!

I.I. Nezgoda, O.N. Naumenko


The urgency of the intestinal yersiniosis problem is explained by increased incidence of this infection in children. In particular, in Vinnytsia region, the incidence of intestinal yersiniosis in 2017 increased almost 3 times (4.5 per per 100,000 children) compared to the same indicator of 2016 (1.4 per 100,000 children). The polymorphism of clinical symptoms, the difficulties of early diagnosis led to the development of severe, generalized forms of infection, especially in young children. The causative agent of yersiniosis is an intracellular Gram-negative microorganism, Y.enterocolitica, which has 31 serotypes. Most isolates belong to serotypes 03 and 09, serotype 03 has a higher enterotoxicity, and 09 — a higher invasiveness. Virulence plasmids carry Y.enterocolitica serotype 03, and due to this, they more often cause generalization of the infectious process. Infection of a person occurs because of consumption of contaminated food stored for a long time in the cold, since high-virulent populations of Yersinia are formed at a low temperature. Due to a variety of clinical symptoms, the multiplicity of damage to the organs and systems, intestinal yersiniosis manifests under the mask of various diseases. The article presents the clinical case of intestinal yersiniosis with fatal outcome. The boy aged 2 years and 2 months was admitted to the infectious hospital on the 10th day of the disease with complaints of fever, hemorrhagic rash, jaundice, edema of face and extremities. Because of atypical manifestations of the initial stage of the infectious process, the child was suspected of having a viral infection with exanthema, and only with the appearance of jaundice and enlargement of the liver and kidneys, the risk of yersinio­sis infection and involvement of respiratory system in the process were suspected. The clinical case presents clinical and laboratory changes in the patient, the results of additional examinations, and also contains a morphological and histological description of the affected organs in autopsy.


intestinal yersiniosis; morbility; generalized forms; children


Dubinskaya GM, Ryabokon’ EV. Clinical description of generalization form of intestinal iersiniosis. Patologia. 2009;6(1):105-106. (in Ukrainian).

Ryabokon’ EV, Dubinskaya GM, Ryabokon’ YuYu. Clinical characteristics of intestinal yersiniosis caused by Yersinia enterocolitica O3 serovar. Zaporožskij medicinskij žurnal. 2009;(52):67-68. (in Ukrainian).

Polishhuk NM, Volzhyn JuM, Kovryga NJa. On some important aspects of the diagnosis and prevention of iersiniosis infection in the territory of Zaporizhzhia region. Zaporožskij medicinskij žurnal. 2008;(5):99-102. (in Ukrainian).

Usachova OV, Silina EA, Konakova OV, Paholchuk TM. Modern clinical features of Yersiniosis in children. Sovremennaya Pediatriya. 2015;(68):48-52. (in Ukrainian).

Centers for Disease Control and Prevention. Foodborne Diseases Active Surveillance Network (FoodNet). Number of Infections and Incidence per 100,000 Persons. Available from: Accessed: March 2, 2016.

Goncharova TE. Ekologo-epidemiologicheskaia kharakteristika psevdotuberkuleza i kishechnogo iersinioza v usloviiakh severo-vostochnogo regiona Ukrainy i puti povysheniia effektivnosti ikh profilaktiki. Diss. kand. med. nauk [Ecological and epidemiological characteristics of pseudotuberculosis and intestinal yersiniosis in the conditions of the north-eastern region of Ukraine and ways to increase the effectiveness of their prevention. PhD diss.]. Кyiv; 1996. 16 p. (in Russian).

Starostina NV. Epidemiologicheskie i ekologicheskie osobennosti zabolevanii, vyzyvaemykh J. fridericsenia, J.kristensenia i J. Intermedia. Diss. kand. med. Nauk [Epidemiological and ecological features of diseases caused by J. fridericsenia, J. kristensenia and J. intermedia. PhD diss.]. Мoscow; 2000. 18 p. (in Russian).

Smirnov IV. Yersinia enterocolitica and related microorganisms. Clinical Microbiology and Antimicrobial Chemotherapy. 2004;6(1):10-21. (in Russian).

Bockemuhl J, Wong J, Bockemuhl J. Yersinia. In: Murray PR, Baron EJ, Pfaller MA, Jordansen JH, Yolken RH, editors. Manual of clinical microbiology. 8th ed. Washington (DC): ASM Press; 2003. 672-683 pp.

Heise T, Dersch P. Identification of a domain in Yersinia virulense factor Yad A that is crucial for extracellular matrix-specific cell adhesion and uptake. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3375-80. doi: 10.1073/pnas.0507749103.

Popova OV, Shepeleva GK, Shestakova IV, Yushchuk ND. Immunological aspects of development of reactive arthrites in Yersinia infection. Infectious Diseases. 2006;4(2):53-58. (in Russian).

Kokorina GI, Shenderovich OA, Tseneva GYa. Use of an immunoblot in the diagnosis of lingering forms of Yersinia infections and in the study of its pathogenesis (a review of literature). Klinicheskaya Laboratornaya Diagnostika. 2006;(11):47-49. (in Russian).

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