DOI: https://doi.org/10.22141/2312-413x.6.4.2018.142473

Features of toxocariasis course in children

T.V. Sorokman, I. Perkas

Abstract


Background. Lack of awareness of physicians, especially pediatricians, about the features of clinical picture and the limitations of laboratory diagnosis of toxocariasis leads to late diagnosis. Most often, toxocariasis is registered under various diagnoses: allergy, chronic pneumonia, dermatitis, etc. The purpose was to study the incidence and peculiarities of the clinical course of toxocariasis in children. Materials and methods. During 2010–2017, 180 children aged 2 to 16 years with a diagnosis of toxocariasis were examined. The comparison group consisted of 50 children with seronegativity for toxocariasis in enzyme-linked immunosorbent assay. A comprehensive survey was conducted using the RIDASCREEN® Toxocara IgG (R-Biopharm, Germany). Statistical processing of the obtained results was performed using Student’s criterion by means of Microsoft Statistica Software, StatSoft, version 6.0. Results. In the structure of parasitosis over the past 7 years, enterobiasis (98 %) is domina­ted, ascariasis (1.5 %) and toxocariasis (0.4 %) are found rarely, the prevalence of other helminthiasis is 0.1 %. In 125 (69.4 %) children suffering from toxocariasis, geophagia and/or the presence of a dog were registered. Analysis on the gender dependence of patients with toxocariasis revealed prevalence of boys — 80 (64 %). Most often, toxocara were found in the age group of 5 to 7 years. The main clinical manifestations of toxocariasis in children were dyspeptic, asthenoneurotic, skin-allergic and respiratory syndromes. All patients with toxocariasis had antibodies, hypochromic anemia, leukocytosis, eosinophilia. Almost half of children with toxocariasis had changes in the hepatobiliary system (elevated alkaline phosphatase, dysproteinemia, hyperenzymemia) with high titres of toxocara antibodies, hepatomegaly, heterogeneity of the liver tissue echostructure, three-phase type of blood flow in duplex scanning and functional disorders of the biliary tract. Conclusions. A relatively high incidence of toxocara invasion among children was detected, as well as key risk factors for infection (geophagia and/or contact with a dog), polymorphism of a clinical manifestation of the disease.

Keywords


children; toxocariasis

References


Yukhimenko GG, Maidannik VG. Toxocarosis in children. Mezhdunarodnyy zhurnal pediatrii, akusherstva i ginekologii. 2012;2(1):124-134. (In Russian).

Zakharchuk OI. Serolesion with toxocariasis of children, living in different climato-geogrophical zones of bukovyna. Buk Med Herald. 2010;(14):32-34. (In Ukrainian).

Sergiev VP. The recorded and true prevalence of parasitic diseases. Meditsinskaya parazitologiya. 2002;(2):3-5. (In Russian).

Macpherson CN. The epidemiology and public health importance of toxocariasis: a zoonosis of global importance. Int J Parasitol. 2013 Nov;43(12-13):999-1008. doi: 10.1016/j.ijpara.2013.07.004.

Anisimova EI, Subbotin AM, Poloz SV. Helminths and helminthiases of domestic predaceous mammals. Minsk, Belaruska navuka; 2013. 187 p. (In Russian).

Sofjin VS, Zavyalov AI, Karakotin AA. Epidemiological aspects of toxocarotic invasion in Saratov region. REAVIZ Bulletin. 2013;(12):19-20. (In Russian).

Lee RM, Moore LB, Bottazzi ME, Hotez PJ. Toxocariasis in North America: a systematic review. PLoS Negl Trop Dis. 2014 Aug 28;8(8):e3116. doi: 10.1371/journal.pntd.0003116.

Romano N, Nor Azah MO, Rahmah N, Lim Y AL, Rohela M. Seroprevalence of toxocariasis among Orang Asli (Indigenous people) in Malaysia using two immunoassays.Trop Biomed. 2010 Dec;27(3):585-94.

Martínez M, Montero J, Pineda A, et al. Epidemiological, clinical and laboratory features of toxocariasis in school children from Aragua State, Venezuela. Trans R Soc Trop Med Hyg. 2018 Jun 1;112(6):255-263. doi: 10.1093/trstmh/try051/.

Borecka A, Kłapeć T. Epidemiology of human toxocariasis in Poland - A review of cases 1978-2009. Ann Agric Environ Med. 2015;22(1):28-31. doi: 10.5604/12321966.1141364.

Gawor J, Borecka A, Marczyńska M, Dobosz S, Żarnowska-Prymek H. Risk of human toxocarosis in Poland due to Toxocara infection of dogs and cats. Acta Parasitol. 2014 Mar;60(1):99-104. doi: 10.1515/ap-2015-0012.

Akao N, Ohta N. Toxocariasis in Japan. Parasitol Int. 2007 Jun;56(2):87-93. doi: 10.1016/j.parint.2007.01.009.

Matos Fialho PM, Correa CRS, Lescano SZ. Seroprevalence of Toxocariasis in Children with Urticaria: A Population-based Study. J Trop Pediatr. 2017 Oct 1; 63(5):352-357. doi: 10.1093/tropej/fmw094.

Li L, Gao W, Yang X, et al. Asthma and toxocariasis. Ann Allergy Asthma Immunol. 2014 Aug;113(2):187-92. doi: 10.1016/j.anai.2014.05.016.

Coşkun F, Akıncı E. Hepatic toxocariasis: a rare cause of right upper abdominal pain in the emergency department. Turkiye Parazitol Derg. 2013;37(2):151-3. doi: 10.5152/tpd.2013.33.




Copyright (c) 2018 ACTUAL INFECTOLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2018

 

   Seo анализ сайта