Significance of hepatitis B virus genotypes in clinical practice
Keywords:HBV infection, HBV genotype, natural progression of HBV infection, liver cirrhosis, hepatocellular carcinoma, hepatitis B transmission routes, chronic hepatitis B
AbstractHepatitis B virus (HBV) infection remains a global public health problem with significant morbidity and mortality. During virus replication, numerous mutations are accumulated, and in the process of phylogenesis it leads to the appearance of HBV genotypes and subgenotypes. HBV has been classified into 10 genotypes (A-J). They have a distinct geographical distribution. In Ukraine, as in other European countries, genotypes A and D prevail. A large number of studies showed a correlation between HBV genotype and the natural progression of the disease, the tendency to chronicity, the rate of HBeAg seroconversion and the response to pegylated interferon alpha treatment. This literature review summarizes results of the studies on the influence of HBV genotypes on the natural progression of the disease. The data on the geographical distribution of HBV genotypes in Ukraine and in the world are given, the significance of determining specific genotypes in terms of their influence on the course and outcome of HBV infection is argued.
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