Oropharyngeal microbiota in children during measles rash

L.A. Volyanska, L.B. Romanyuk, E.I. Burbela, I.L. Gorishna


Background. The purpose of our work was to study the oropharyngeal microbiota in children with measles. Materials and methods. We observed 35 children who got sick with a typical form of measles and were hospitalized. Among the exa­mined children, 23 (65.7 %) patients had an uncomplicated course, the rest 12 (34.3 %) patients had measles complicated by pneumonia, bronchitis or otitis. Material from the oropha­rynx in the period of rash was investigated by microbiological method. Clarifying identification was performed using a semi-automatic microbiological analyzer Vitek-2. To estimate the frequency of various microorganisms on the mucous membrane of the oropharynx in the population, we used the indicator of (Rі) incidence, the degree of domination of one or ano­ther representative of the microbiota in the group was determined by the frequency of its appearance in the samples, ­using the constancy index (C, %). Statistical data processing was carried out using the standard software package for a personal computer. Results. A study of the oropharyngeal microbiota in observed children with measles found the dominance of obligately resident microorganisms: α- and β-hemolytic Streptococci, Lactobacillus spp., Neisseria spp. Representatives of the transient microbiota were Enterobacter spp., Pseudomonas spp. and Micrococcus spp. Elective resident flora of the oropha­rynx was composed  by microorga­nisms: Staphylococcus spp., particulary S. aureus, Streptococcus spp. and with γ-hemolysis, Corynebacterium spp., Moraxella spp., Candida spp. and E. coli and Enterococcus spp. Streptococci value reached the maximum indicator of the incidence of microorganisms (Pu) in the oropharynx of patients with measles, α- and β-hemolytic Streptococci appeared with the same frequency. Conclusions. Thus, in children with measles, there is a violation of the oropharyngeal normocenosis, which is manifested with a decrease in the constancy index (C) and the rate of the incidence of Pi constant strains of Staphylococcus spp., Neisseria spp. and Lactobacillus spp. An increased index of constancy and incidence indicator indicates a violation of the normocenosis at the border with dysbiosis of the oropharynx in children with measles. Increased ration of α-, γ- and β-hemolytic Streptococci in combination with the expressed factors of their pathogenicity is a probable cause of bacterial complications of Streptococcal etiology.


measles; children; oropharyngeal microbiota


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