DOI: https://doi.org/10.22141/2312-413x.8.5-6.2020.217956

Studying the prevalence and resistance to antimycotics of fungi of genus Candida in infectious diseases of the upper and lower respiratory tract

N.I. Kovalenko, T.M. Zamazii, I.V. Novikova

Abstract


The study found that the leading role in the etiology of infectious diseases of the upper and lower respiratory tract belonged to the viridans group streptococci and fungi of the genus Candida. The proportion of fungi of the genus Candida was 28.8 % in patients with pharyngitis, 22.6 % in those with bronchitis and 37.4 % in individuals with pneumonia, which in 77–85.6 % of ca-ses were present in associations with bacteria. There is a high level of resistance of fungi of genus Candida to triazole antifungals.


Keywords


fungi of the genus Candida; infectious diseases of the upper and lower respiratory tract

References


Pendleton M.K., Huffnagle G.B., Dickson R.P. The significance of Candida in the human respiratory tract: our evolving understanding. Pathogens and Disease. 2017 April. Vol. 75, Issue 3. https://doi.org/10.1093/femspd/ftx029.

Hofs S., Mogavero S., Hube B. Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J. Microbiol. 2016. Vol. 54. P. 149­169.

Krause R., Halwachs B., Thallinger G. et al. Characterisation of Candida within the mycobiome/microbiome of the lower respiratory tract of ICU patients. PLoS One. 2016. Vol. 11. Е0155033.

European Centre for Disease Prevention and Control. Surveillance of antimicrobial resistance in Europe. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS­Net) for 2017. Stockholm: ECDC, 2018. 108 p. Available from: http://ecdc.europa.eu/ publications­data/ears­net­reporting­protocol­2018.

Собкова Ж.В., Костенко И.Г., Покас Е.В. Кандиды. Свойства и роль в этиологии заболеваний человека (часть 4). Український медичний вісник. 2015. № 3(96). Режим доступа: http://therapia.ua/therapia/2015­/3­96/kandidy­svoistva­i­rol­v­etiologii­zabolevanii­cheloveka­chast­41.

Hamet M., Pavon A., Dalle F. et al. Candida spp. airway colonization could promote antibiotic­resistant bacteria selection in patients with suspected ventilator­associated pneumonia. Intensive Care Med. 2012. Vol. 38. P. 1272­1279.

Roux D., Gaudry S., Khoy­Ear L. et al. Airway fungal colonization compromises the immune system allowing bacterial pneumonia to prevail. Crit. Care Med. 2013. Vol. 41. P. 191­199.

Goіbek K. Selected mechanisms of molecular resistance of Candida albіcans to azole drugs. Acta Biochim. Pol. 2015. Vol. 21. P. 47­52.

Canton R., Morosini M.I. Emergence and spread of antibiotic resistance following exposure to antibiotics. FEMS Microbiol. Rev. 2011. Vol. 35. № 5. P. 977­991.

Приказ МЗ СССР № 535 от 22.04.1985 г. «Об унификации микробиологических (бактериологических) методов исследования, применяемых в клинико­диагностических лабораториях лечебно­профилактических учреждений». М., 1985. 62 с.

Наказ МОЗ України № 167 від 05.04.07 «Про затвердження методичних вказівок «Визначення чутливості мікроорганізмів до антибактеріальних препаратів». К., 2007. 52 с.

Сміянов В.А., Івахнюк Т.В. Проблема кандидозно­бактеріальних асоціацій при захворюваннях ЛОР­органів. Новости медицины и фармации. 2007. № 17(224). Режим доступу: http://www.mif­ua.com/archive/article/3804




Copyright (c) 2020 ACTUAL INFECTOLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2020

 

   Seo анализ сайта