Peculiarities of a humoral immune response in coronavirus infection (COVID-19)


  • O.M. Zinchuk Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
  • A.V. Petrukh Diagnostic Center “MeDIS”, Lviv, Ukraine
  • N.I. Hrynchyshyn Diagnostic Center “MeDIS”, Lviv, Ukraine
  • К.К. Shvaievska Diagnostic Center “MeDIS”, Lviv, Ukraine



coronavirus, COVID-19, immunoglobulin, enzyme-linked immunosorbent assay


We reviewed scientific data published during the recent 12 months about peculiarities of a humoral immune response in coronavirus infection (COVID-19). We also examined the concentration of immunoglobulin G against SARS-CoV-2 in 65 people in the Diagnostic Center “MeDIS” in 2020 with the diagnostic titer of specific antibodies. We established that in 3 months after primary examination of serum 60 % of examined patients presented high titers of IgG against SARS-CoV-2 (seropositivity rate > 7) in ELISA test. The highest level of IgG against SARS-CoV-2 in 3 months after the primary examination was revealed in those with a high initial level of antibodies against this virus.


Centers for Disease Control and Prevention. Interim Guidelines for COVID-19 Antibody Testing in Clinical and Public Health ­Settings.­antibody-tests-guidelines.html

Deeks J.J., Dinnes J., Takwoingi Y. et al. Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Database Syst. Rev. 2020. 6. CD013652.

To K.K., Tsang O.T., Leung W.S. et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect. Dis. 2020. 20. 565.

Wölfel R., Corman V.M., Guggemos W. et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020. 581. 465.

Lynch K.L., Whitman J.D., Lacanienta N.P. et al. Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity. Clin. Infect. Dis. 2020.

Rijkers G., Murk J.L., Wintermans B. et al. Differences in Antibody Kinetics and Functionality Between Severe and Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infections. J. Infect. Dis. 2020. 222. 1265.

Dan J.M., Mateus J., Kato Y. et al. Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science. 2021.

Isho B., Abe K.T., Zuo M. et al. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020. 5.

Iyer A.S., Jones F.K., Nodoushani A. et al. Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients. Sci Immunol. 2020. 5.

Gudbjartsson D.F., Norddahl G.L., Melsted P. et al. Humoral Immune Response to SARS-CoV-2 in Iceland. N. Engl. J. Med. 2020. 383. 1724.

Long Q.X., Tang X.J., Shi Q.L. et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat. Med. 2020. 26. 1200.

Lumley S.F., O’Donnell D., Stoesser N.E. et al. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Wor­kers. N. Engl. J. Med. 2020.

Robbiani D.F., Gaebler C., Muecksch F. et al. Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature. 2020. 584. 437.

Wajnberg A., Amanat F., Firpo A. et al.. Robust neutralizing antibodies to SARS-CoV-2 infection persist for months. Science. 2020.

Wang K., Long Q.X., Deng H.J. et al. Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection. Clin. Infect. Dis. 2020.

Self W.H., Tenforde M.W., Stubblefield W.B. et al. Decline in SARS-CoV-2 Antibodies After Mild Infection Among Frontline Health Care Personnel in a Multistate Hospital Network — 12 States, April — August 2020. MMWR Morb. Mortal. Wkly Rep. 2020. 69. 1762.

Qu J., Wu C., Li X. et al. Profile of IgG and IgM antibo­dies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin. Infect. Dis. 2020 Apr 27.

Hansen K.E., Caliendo A.M., Arias C.A. et al. Infectious Di­seases Society of America Guidelines on the Diagnosis of COVID-19: Serologic Testing. Auguest 18, 2020.

World Health Organization. Diagnostic testing for SARS-CoV-2: interim guidance. 2020.

Coronavirus (COVID-19) Update: FDA Authorizes First Test that Detects Neutralizing Antibodies from Recent or Prior SARS-CoV-2 Infection. November 06, 2020.

В Україні зареєстровано майже 600 випадків повторних заражень COVID-19. МОЗ України, лютий 2021 року.





Original Researches