Clinical Efficiency of Application of Intravenous Immunoglobulin in Pregnant Women with Intrauterine Infection

O.L. Ishchenko, I.P. Krokhmal, S.M. Serhiienko, I.O. Kovtoniuk


The problem of intrauterine infection (IUI) is still relevant today. Ineffective treatment of this pathology is associated with physiological decline of the immunity in these patients. We have proposed the additional use of intravenous immunoglobulin for the treatment of pregnant women with IUI. There were examined 75 patients with IUI, which was diagnosed in the II trimester. The I group consisted of 40 individuals who received conventional treatment, the II group was formed from 35 women who additionally received intravenous immunoglobulin. On the background of IUI, pregnancy was characterized by an increased incidence of threatened miscarriage and premature labor, gestosis and placental dysfunction; during delivery, premature rupture of amniotic membrane and fetal distress were more common. These patients had placenta with both ultrasonic and histological signs of infection. Among newborns, there was a significant increase in the incidence of pathology associated with intrauterine infection. Additional use of intravenous immunoglobulin in the treatment of IUI during the II trimester of pregnancy in comparison with conventional therapy leads to a significant reduction in the incidence of both obstetric complications and perinatal pathology.


intravenous immunoglobulin; intrauterine infection; pregnancy complications; neonatal pathology


Arkhypova NA, Hrytsay IM, Danylkiv OO. [Analysis of pregnancy, perinatal losses and the state of providing specialized care for pregnant women with kidney disease]. Zdorove zhenschinyi. 2009;3(39):55-58.Ukrainian.

Krasnopolskiy VP, Tareeva TG, Malinovskaya VV. [System of the immunocorrection in chronic infectious and inflammatory diseases in pregnant women]. Rossiyskiy vestnik akushera-ginekologa. 2004;(1):36-38. Russian.

Nikonov AP, Astsaturova OR. [Infection in obstetrics and gynecology. A Practical Guide to Diagnosis and Antimicrobial Chemotherapy. Methodical recommendations]. Infektsii i antimikrobnaya terapiya. 2004;6(3):65-72. Russian.

Sidorova IS, Makarov IO, Matvienko NA. Vnutriutrobnaya infektsiya. Vedenie beremennosti, rodov i poslerodovogo perioda [Prenatal infection. Conducting pregnancy, delivery and postpartum period]. Moskva: MEDpress-ynform; 2012. 160p. Russian.

Simrok VV, Sivtsov SS. [Features of medical tactic in pregnant women with cervical incompetence on the background inaparantnyh forms of infection]. Aktualnaya infektologiya. 2013;1(1):53-55. Ukrainian.

Sudoma IO, Chernyshov VP. [How to contact peripheral immune status in patients with infertility with in vitro fertilization programs' performance and place of immunotherapy in combination means improving the effectiveness of treatment]. Klinichna farmatsiya. 2005;9(3):15-20. Ukrainian.

Suhih GT, Vanko LV. Immunologiya beremennosti [Immunology of pregnancy]. Moskva: Meditsina; 2003. 420p. Russian.

Tsinzerling VA, Melnikova VF. Perinatalnyie infektsii. Voprosyi patogeneza, morfologicheskoy diagnostiki i kliniko-morfologicheskih sopostavleniy. Рrakticheskoe rukovodstvo]. Sankt-peterburg: Meditsina; 2002. 352p. Russian.

Yunkerov VI. Matematiko-statisticheskaya obrabotka dannyih meditsinskih issledovaniy [Mathematical and statistical processing of medical research]. Sankt-peterburg: VMedA; 2002. 266 p. Russian.

Copyright (c) 2016 ACTUAL INFECTOLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта