On the Issue of Herpes Infection as an Actual Problem Nowadays
Among persistent intracellular agents, a group of herpesviruses occupies the leading place after the prevalence. The World Health Organization (WHO) warns the international community of the danger of latent herpes infection pandemic. According to the WHO, 70 to 90 % of the world population is infected with one or more types of herpes virus, and in 50 % of them, due to the absence of stable immunity, disease relapses occur annually. The family of herpes viruses found in humans includes herpes simplex virus type 1 and 2, Zoster virus, cytomegalovirus, Epstein-Barr virus, human herpes type 6, 7, 8. Thus, in the pathogenesis of herpes infection type 1 and 2, there are four main phases: the penetration of the epithelial cells → penetration into the nerve endings and paravertebral ganglia → elimination of the virus from tissues and organs → reactivation of herpes simplex virus and moving it to the port of infection. Herpetic and cytomegalovirus infection that belongs to the group of TORCH infections is the most common cause fetal infection, which can lead to the birth of a child with disabilities. Herpesvirus infections are considered as a group of infections associated with human immunodeficiency syndrome, and is a common cause of damage to the central nervous system and internal organs in patients with secondary immunodeficiency. Almost all known now human herpesviruses can cause damage to the nervous system. In this regard, herpes infections have become one of the leading medical and social problems and acquire national importance.
Abaturov OYe, Vysochy IL. [The immunotrop effect from “Flavozid”]. Sovremennaya pedyatryya. 2008;4(21):99-102.Ukrainian
Znamenskay ТК, Pysarev AA. [Treatment of herpes infections (cytomegalovirus, neonatal herpes) in children under 1 year using]. Zdorove zhenshhynu.2009;4 (40): 60-61. Russian
Kazmyrchuk VE, Malcev DV. [A retrospective analysis of the drug Gerpimun-6 in patients with infections caused by virus type 6 herpes ]. Klin. imunologiya, alergologiya, infektologiya. 2010;5–6(34–35):64–70. Russian
Koloskova OK, Ivanova LA, Byelashova OV; authors. [Features of the modern flow of encephalitis in children (Review of clinical cases)]. Aktual'naya ynfektolohyya. 2015;2(7):23-29. Ukrainian
Kramaryev SO, Vygovska OV, Palatna LO; authors. [The use of the drug "Flavozyd" in the treatment of chronic active Epstein - Barr virus infection in children]. Sovremennaya pedyatryya. 2008; 3(20):111-114. Ukrainian
Malcev DV, Kazmirchuk VYe. [The effective of antiviral treatment for herpes neuroinfections with temporal lobe epilepsy]. Mizhnarod. nevrol. zhurn. 2011;4(42): 21–28. Ukrainian
Chop'yak VV, Potomkina GO, Valchuk IV. [Efficiency of montherapy whith proteflazid in treatment of patients with chronic EBV-viral infection in the stage of reactivation]. Imunologiya ta alergologiya. 2008;1:3-9. Ukrainian
Shamsiev FM, Mirsalihova NH, Alimova KI, Tadzhihanova DP. [State of the immune status and effectiveness of proteflazid in the complex therapy of children with bronchopulmonary pathology associated with TORCH-infection]. Sovremennaya pedyatryya. 2011;2 (36): 39-41. Russian
Yulish YeI, Gadeczka SG, Balychevceva IV; authors. [Etiopathogenetic therapy of recurrent respiratory infections in young children in the background of all course persistent infections]. Doneczk; 2010. 48p. Ukrainian
Yaroshenko SYa. [Rehabilitation of children with high incidence of acute respiratory infections, living in Closed Child institutions. nauk: specz. 14.01.10 “Pediatriya” ]. Doneczk: Doneczkyj. nacz. med. un-t im. M. Gorkogo, NDI med. probl. sim'yi; 2011. 25p. Ukrainian
Bao L, Cowan MJ, Dunham K. Adoptive immunotherapy with CMV-specific cytotoxic T lymphocytes for stem cell transplant patients with refractory CMV infections. Immunother. 2012;35(3): 293–298. (PMID:22421947[PubMed - indexed for MEDLINE] PMCID:PMC3306600 Free PMC Article) doi: 10.1097/CJI.0b013e31824300a2.
Doubrovina E, Oflaz-Sozmen B, Pro¬ckop SE. Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation. Blood. 2012;119(11):2644–2656. (PMID: 22138512[PubMed - indexed for MEDLINE] PMCID:PMC3311278 Free PMC Article) doi: 10.1182/blood-2011-08-371971. Epub 2011 Dec 2
Nigro G, Adler SP, Parruti G. [Immunoglobulin therapy of fetal cytomegalovirus infection occurring in the first half of pregnancy - a case-control study of the outcome in children ] J. Infect. Dis. 2012;205(2): 215–227. PMID: 22140265 [PubMed - indexed for MEDLINE] Free full text doi: 10.1093/infdis/jir718. Epub 2011 Dec 2.
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