Features of Noro- and Adenovirus Intestinal Infections in Children

L.O. Palatna, A.B. Vilenskyi, N.B. Pranik, S.O. Renchkovska

Abstract


The clinical and laboratory features of viral intestinal infections caused by norovirus (11), adenovirus (9) and noro-adenovirus (4) in 24 hospitalized children were investigated in non-epidemic period for these infections (April-November 2014). Etiological diagnosis was performed when studying faeces by polymerase chain reaction (PCR). The study found that these infections occurred mostly in late summer and in autumn as gastroenteritis of moderate severity, manifested mainly in children under 3 years old. Norovirus infection was more severe than adenovirus one due to the presence of hyperthermic syndrome, frequent intensive vomiting at the onset of the disease, which justify the rapid admission of patients to inpatient department (in the first 6–12 hours of disease). In most children we have detected exsiccosis of I–II degree. Almost half of the children revealed severe ketonuria, leukocytosis and/or leukocyte formula shift to the left with the normalization of blood formula during the first day of treatment. This necessitates the etiological diagnosis of gastroenteritis in children involving PCR without a break for the summer and autumn to avoid unjustified antibiotic therapy.


Keywords


norovirus; adenovirus; viral gastroenteritis; acute intestinal infection

References


Arcangeletti MC, Germini D, Martorana D, Rodighiero I, De Conto F, Medici MC, Chezzi C, Calderaro A. High frequency of cultivable human subgroup F adenoviruses in stool samples from a paediatric population admitted to hospital with acute gastroenteritis. J Med Microbiol 2014;63(Pt 6):812-8. doi: 10.1099/jmm.0.072413-0.

Chen SY, Tsai CN, Chen CL, Chao HC, Lee YS, Lai MW, Chen CC, Huang WL, Chiu CH. Severe viral gastroenteritis in children after suboptimal rotavirus immunization in Taiwan. Pediatr Infect Dis J 2013;32(12):1335-9. doi: 10.1097/INF.0b013e3182a5f5b6.

Colas de la Noue A, Estienney M, Aho S, Perrier-Cornet JM, de Rougemont A, Pothier P, Gervais P, Belliot G. Absolute humididty influences the seasonal persistence and infectivity of human norovirus. Appl Environ Microbiol. 2014. pii: AEM.01871-14.

Fletcher S, Van Hal S, Andresen D, McLaws ML, Stark D, Harkness J, Ellis J. Gastrointestinal pathogen distribution in symptomatic children in Sydney, Australia. J Epidemiol Glob Health 2013;3(1):11-21. doi: 10.1016/j.jegh.2012.11.004.

Karst SM, Zhu S, Goodfellow IG. The molecular pathology of noroviruses. J Pathol 2015;235(2):206-16. doi: 10.1002/path.4463.

Ku MS, Sheu JN, Lin CP, Chao YH, Chen SM. Clinical characteristics and outcome in norovirus gastroenteritis. Indian J Pediatr 2014;81(12):1321-6. doi: 10.1007/s12098-014-1419-2.

Puacz E, Cwikła S, Piasecka-Twar?g M. Analysis of norovirus and rotavirus infections of patients hospitalized in the general specialist hospital in Lublin. Retrospective studies. Med Dosw Mikrobiol 2013;65(1):57-64.

Sai L, Sun J, Shao L, Chen S, Liu H, Ma L. Epidemiology and clinical features of rotavirus and norovirus infection among children in Ji’nan, China. Virol J 2013;10:302. doi: 10.1186/1743-422X-10-302.

Saikruang W, Khamrin P, Suantai B, Okitsu S, Hayakawa S, Ushijima H, Maneekarn N. Detection of diarrheal viruses circulating in adult patients in Thailand. Arch Virol 2014;159(12):3371-5. doi: 10.1007/s00705-014-2191-3.

Sung K, Kim JY, Lee YJ, Hwang EH, Park JH. High incidence of staphylococcus aureus and norovirus gastroenteritis in infancy: a single-center, 1-year experience. Pediatr Gastroenterol Hepatol Nutr 2014;17(3):140-6. doi: 10.5223/pghn.2014.17.3.140.

Wiegering V, Kaiser J, Tappe D, Weissbrich B, Morbach H, Girschick HJ. Gastroenteritis in childhood: a retrospective study of 650 hospitalized pediatric patients. Int J Infect Dis 2011;15(6):e401-7. doi: 10.1016/j.ijid.2011.02.006.

Doroshina E. A. Kliniko-epidemiologicheskie osobennosti i voprosyi terapii norovirusnoy infektsii u detey: dis.. kand. med. nauk.: 14.00.10 / Doroshina Elena Aleksandrovna; FGUN «Tsentralnyiy nauchno-issledovatelskiy institut epidemiologii» Federalnoy sluzhbyi po nadzoru v sfere zaschityi prav potrebiteley i blagopoluchiya cheloveka – M., 2009. – 106.

Levin D.Yu. Kliniko-laboratornaya harakteristika norovirusnoy infektsii u detey / D.Yu.Levin, A.A. Kadura // Byulleten meditsinskih internet-konferentsiy. – 2013. - Vyipusk N2, T. 3. – Rezhim dostupu: http://cyberleninka.ru/article/n/kliniko-laboratornaya-harakteristika-norovirusnoy-infektsii-u-detey

Shestakova I.V. Norovirusnaya infektsiya / I.V. Shestakova // Consilium medicum. - 2013.- N12. - S. 34-37.




DOI: https://doi.org/10.22141/2312-413x.1.06.2015.78425

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