DOI: https://doi.org/10.22141/2312-413x.2.07.2015.78617

Clinical and Paraclinical Features of Atopic Dermatitis Associated with Violations of Intestinal Microbial Landscape in Infants

O.K. Koloskova, U.I. Marusyk, N.V. Kordunian

Abstract


The objective of the work was to study the diagnostic value of clinical and paraclinical indicators in children with manifestations of intestinal dysbiosis on the background of atopic dermatitis to improve the treatment efficacy in this disease. There has been carried out a comprehensive observation of 26 children of the first year of life, who had clinical signs of atopic dermatitis. According to bacteriological stool culture, children were divided into two clinical groups. First group consisted of 19 children with significant violations in composition of intestinal microflora, which manifested by dysbiosis of II–III degree. The remaining patients with no signs of intestinal dysbiosis (according to bacteriological examination of stools) were included in the second clinical group. The complex examination consisted of clinical assessment of changes in the skin by Eczema Area and Severity Index, according to which the area of skin lesion and severity of morphological elements of rashes, as well as complete blood count and the levels of total immunoglobulin E were evaluated. The studies found that the pathologic disorder of intestinal microbiota in children with atopic dermatitis increases the risk of severe course of this disease by 2.8 times, and the risk of high levels of total immunoglobulin E in blood serum > 130.0 IU/ml almost by 5 times (odds ratio — 4.8 (95% confident interval 2.4–9.5)).


Keywords


dysbiosis; atopic dermatitis; intestine; children

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