Diagnostic Value of Specific Markers in the Verification of Bacterial Nature of the Inflammatory Processes n the Respiratory System

O.K. Koloskova, L.A. Ivanova, T.M. Bіlous, R.I. Goncharuk


Introduction. Recently, there are accumulated more data on the role of infection as a risk factor for wheezing syndrome, bronchial asthma (BA) and its exacerbations, which often calls for differential diagnosis with such complications, as pneumonia of bacterial or viral etiology. Objective of the study: in order to improve the diagnosis of bacterial inflammations of the airways in children of all ages to explore some results of the patients’ survey. Materials and methods. Comprehensively, we have examined 279 sick children, from infancy to the preschool age. The first (I) clinical group consisted of 100 infants, who were admitted to the hospital for community-acquired bacterial pneumonia (BP). The second (II) group included 56 children with asthma, in whom we have confirmed the bacterial nature of febrile asthma attacks. The third (III) group consisted of 46 BA patients with confirmed viral nature of febrile asthma exacerbations. The fourth (IV) group included 77 infants with acute respiratory viral infection (ARVI) in the form of acute bronchitis (45 children), bronchiolitis (15 cases) and viral pneumonia (17 patients). Results and their discussion. The white blood cell count of the peripheral blood revealed in patients with BP the presence of bacterial and inflammatory process in contrast to peers with ARVI. The study of C-reactive protein concentrations in the blood serum allowed us to obtain the following results: the average content of this protein and in I clinical group was 67.26 ± 4.90 mg/l, in IV group — 22.39 ± 4.40 mg/l, in II group — 56.2 ± 2.6 mg/l and in III comparison group— 28.8 ± 2.4 mg/l (PI : II, III, IV; II : III, IV < 0.05). Conclusions. Consequently, none of the studied clinical and paraclinical markers have an independent diagnostic value in confirming bacterial inflammation.


Juven T, Mertsola J, Waris M, Leinonen M, Meurman O. [Etiology of community-acquired pneumonia in 254 hospitalized children]. Pediatr. Infect. Dis. J. 2000;19:293-298. English.

Gern JE, Lemanske RF. [Infectious triggers of pediatric asthma]. Pediatr Clin North Am. 2003;50(3):555-575. English.

Regnejo HI, Gnerra ML, Dos Santos M, Cocorra AM. [Immunodiagnoses of community-acquired pneumonia in childhood]. Trop. Pediatr. 1997;43:208-212.

McCracken GH. [Etiology and treatment of pneumonia]. Pediatr. Infect. Dis. J. 2000;19:373-377. English.

Pifferi M, Maggi F, Andreoli E. [An important virus in asthma pathophysiology?]. J. Infect. Dis. 2005;192:1141-1148. English.

Prober CG. [Pneumonia. In: Textbook of Pediatrics. Behrman R.E., Kliegman R.M., Jenson H.B.]. W.B. Saunders Company: Philadelphia – Tokyo; 2000: P. 761-764; 992-993. English.

Howard TS, Hoffman LH, Stang PE, Simoes AF. [Respiratory syncytial virus pneumonia in the hospital setting: Length of stay, charges, and mortality]. J. Pediatr. 2000;137:227-232. English.

Toikka P, Irjala K, Juven T, Virkki R, Mertsola J. [Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children]. Pediatr. Infect. Dis. J. 2000;19:598-602. English.

Sing AM, Busse WW. [Asthma exacerbations. 2: Ethyology]. Thorax. 2006;61:809-816. English.

Pavord ID, Pizzichini MM, Pizzichini E, Hargreave FE. [The use of induced sputum to investigate airway inflammation]. Thorax. 1997;52(2):498-501. English.

Wark PAB, Gibson PG. [Asthma exacerbations. 3: Pathogenesis]. Thorax. 2006;61:909-915. English.

Volyanska LA, Burbela EI, Mudryk UM, Yevtushenko SV. [An innovative approach to the individualization of treatment of children with acute respiratory infections]. Aktualna insektologiya. 2016;10(1):60-64. Ukrainian

DOI: https://doi.org/10.22141/2312-413x.3.12.2016.81712


  • There are currently no refbacks.

Copyright (c) 2016 ACTUAL INFECTOLOGY

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2017


 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru