Features of Clinical and Biochemical Parameters and Indicators of Neurohumoral Regulation in Patients with Chronic Hepatitis C and Mixed Cryoglobulinemia Depending on the Infection with Different HCV Genotypes
Purpose. To identify the features of clinical and biochemical parameters and indicators of neurohumoral regulation in patients with chronic hepatitis C and mixed cryoglobulinemia depending on the infection with different genotypes of hepatitis C virus (HCV). Methods. The study involved 78 patients with chronic hepatitis C and mixed cryoglobulinemia. The content of cryoglobulins in the blood serum was determined by spectrophotometry, of cortisol — by enzyme immunoassay. We have evaluated the spectral parameters of heart rate variability using computer cardiointervalometry. Patients were divided into 2 groups: 42 patients infected with HCV genotype 1 and 36 patients infected with HCV genotype 2 or 3. Results. There was no statistically significant difference in the clinical signs of mixed cryoglobulinemia, alanine aminotransferase activity and the content of mixed cryoglobulins in the blood serum of patients infected with HCV 1 and 2 or 3 genotype. Serum cortisol was 20.6 % higher (p < 0.05) in patients infected with HCV genotype 1. The analysis of heart rate variability showed that low frequency was lower by 24.5 % (p < 0.05), and the rate of high frequency — higher by 60.4 % (p < 0.05) in patients infected with HCV genotype 1. Therefore, patients infected with the HCV genotype 1 had a more significant imbalance of neurohumoral regulation.
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Negro F, Forton D, Craxì A. Extrahepatic morbidity and mortality of chronic hepatitis. Gastroenterology. 2015; 149(6): 1345-60.
Jacobson IM, Cacoub P, Maso L. Manifestations of chronic hepatitis C virus infection beyond the liver. 2010; 8(12): 1017-29.
Cacoub P, Comarmond C, Domont F. Extrahepatic manifestations of chronic hepatitis C virus infection. Ther. Adv. Infect. Dis. 2016; 3(1): 3-14.
Cacoub P, Comarmond C, Domont F. Cryoglobulinemia Vasculitis. Am. J. Med. 2015; 128(9): 950-5.
Rosenthal E, Cacoub P. Extrahepatic manifestations in chronic hepatitis C virus carriers. Lupus. 2015; 24(4-5): 469-82.
Ryabokon YuYu. Autoimmune disorders in patients with chronic hepatitis C with varying degrees of severity mixed cryoglobulinemia. Bukovinskiy medichniy vIsnik. 2012; 16/ 3 (63), 80-83. Ukrainian.
Ramos-Casals M, Stone J.H. The cryoglobulinaemias. Lancet. 2012; 379. p. 348-360.
Wang Q, Wang M, Whim MD,. Neuropeptide y gates a stress-induced, long-lasting plasticity in the sympathetic nervous system. J Neurosci. 2013; 33. 12705-12717; doi:10.1523/JNEUROSCI.3132-12.2013; PMID:23904607; PMCID:PMC3728685.
Frayn KN. Fat as a fuel: emerging understanding of the adipose tissue-skeletal muscle axis. Acta Physiologica. 2010; 199(4): 509-518.
Uchoa ET, Aguilera G, Herman JP. Novel aspects of glucocorticoid actions. J. Neuroendocrinol. 2014; 26( 9): 557-572.
Shields RW, Jr. Heart rate variability with deep breathing as a clinical test of cardiovagal function. Cleve Clin. J. Med. 2009; 76: 37-40.
Peretyagin SP, Martusevich AK, Borisov, VI. Investigation of the features of heart rate variability in patients with burns. Vestnik anesteziologii i reanimatologii. 2011. 4: 10-14. Russian.
Plotnikova Eyu, Maksimov SA. Autonomic aspects of the pathology of the biliary tract. Ros. zhurn. gastroenterologii, gepatologii, koloproktologii. 2009; 1. 106. Russian.
Zaytsev IA, KIrIenko VT, MIroshnichenko VO. Quality of life related to health of patients with chronic hepatitis C who are unaware of the presence of hepatitis C. 2009; 1(1): 43-49. Ukrainian.
Radaeva EV, Govorin AV, Chistyakova MV. The syndrome of autonomic dysfunction in patients with chronic hepatitis C. Far East Medical Journal. 2014; 1: 49-52. Russian.
Reshetnikov AA, Shuldyakov AA, Safonova MV. Heart rate variability in patients with chronic brucellosis: Autonomic regulation. Saratovskiy nauchno-meditsinskiy zhurnal. 2009; 5(4) : 578-580. Russian.
Vigani AG, Pavan MH, Tozzo R. Comparative study of patients with chronic hepatitis C virus infection due to genotypes 1 and 3 referred for treatment in southeast Brazil. BMC Infect Dis. 2008; 164 (8): 82-88.
Kahloun A, Babba T, Fathallah B. Prevalence of extra-hepatic manifestations in infection with hepatitis C virus: study of 140 cases. Tunis Med. 2011; 89(6): 557-60.
Nalobina AN, Methodology to evaluate the adaptive processes in infants. Uchenyie zapiski universiteta imeni P.F. Lesgafta. 2013; 3 (97): 145-150. Russian.
Ban AS, Paramanova NA, Zagorodnyiy GM. Analysis of the relationship heart rate variability. Voennaya meditsina. 2010; 4: 21-24. Russian.
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