Contraceptive Vaccines

M.V. Supotnitsky

Abstract


Researches to develop vaccines with contraceptive effect are being carried out since the 1920s. Since 1972, the contraceptive vaccines are one of the priority programs of the World Health Organization (WHO Special Programme of Research, Development and Research Training in Human Reproduction). Rockefeller Foundation participates in implementing the program. Openly declared objective of creating such vaccines — the regulation of the population in the Third World countries. There are currently three main directions of contraceptive vaccine design: 1) vaccines targeted at blocking the production of gametes; 2) impairing their function; 3) violating the fertilization process. Contraceptive vaccines for more than 10 years are widely used to reduce fertility and castration of wild and domestic animals. In the commercial realization there are veterinary vaccines Equity®, Improvac®, GonaCon®, Repro-BLOC (based on gonadotropin-releasing hormone); SpayVac™ and IVT-PZP® (based on zona pellucida antigens). Clinical studies have shown effective contraceptive action (in women) of vaccines, in which human chorionic gonadotropin is used as an antigen. At the same time, there are found the side effects of such vaccines: for vaccines containing gonadotropin-releasing hormone and luteinizing hormone as antigenic components — castration, impotence; for vaccines containing follicle stimulating hormone — oligospermia; zona pellucida antigens — irreversible oophoritis. This paper discusses approaches to detection of sterilizing components in vaccines intended for mass prevention of infectious diseases, not reported by manufacturers, and the consequences of their use. Hidden use of contraceptive vaccines, which already took place, can be detected: 1) by the presence of antibodies to their antigenic components (in unvaccinated by contraceptive vaccines people such antibodies do not exist, except infertility cases); 2) by change in the hormonal levels of the vaccinated patients; 3) by malfunction and histopathological changes in the reproductive organs.


Keywords


azoospermia; antigens; sperm; antibodies; oocyte zona pellucida; gonadotropin-releasing hormone; immunocontraception; contraceptive vaccine; luteinizing hormone; follicle stimulating hormone; human chorionic gonadotropin

References


Aitken R.J., Rudak E.A., Richardson D.W., Dor J. et al. The influence of anti-zona and anti-sperm antibodies on sperm-egg interactions // J. Reprod. Fert. — 1981. — V. 62. — P. 597-606.

Anil Suri. Sperm specific proteins-potential candidate molecules for fertility control // Reproduc. Biol. Endocrin. — 2004. — V. 2 (электронный ресурс: http://www.rbej.com/content/2/1/10).

Anthony M.B., Roger A., Bulter C. WO 91/04052. Vaccines // Peptide Technology Ltd. (Австралия). Заявл. 22.09.1989; опубл. 04.04.1991.

Bahl O.P. GB2051081. Antigen for early pregnancy test and contraceptive vaccine // Research Corp. (США). Заявл. 06.02.1978; опубл. 14.01.1981.

Baskin M.J. Temporary sterilization by injection of human spermatozoa: a preliminary report // Am. J. Obstet. Gynecol. — 1932. — V. 24. — P. 892-897.

Baskin M.J. US2103240. Nonspecific spermatoxic vaccine and process of producing same (США). Заявл. 07.08.1935; опубл. 28.12.1937.

Blastocyst. Электронный ресурс http://en.wikipedia.org/wiki/Blastocyst.

Bowen R.L. NZ533463 (A). Methods for slowing senescence and treating and preventing diseases associated with senescence / Voyager Pharmaceutical Corp (США). Заявл. 19.12.2002; опубл. 23.02.2007.

Brown R., Mansour M., Pohajdak B. EP1474447 (A2). Antigens for immunocontraception // Immunovaccine Technologies Inc. (Канада). Заявл. 08.02.2002; опубл. 10.11.2004.

Calcium channel. Электронный ресурс http://en.wikipedia.org/wiki/Calcium_channel.

Edwards R.G. Immunological control of fertility in female mice // Nature. — 1964. — V. 203. — P. 50-53.

Engdahl F. Seeds of Destruction. The Hidden Agenda of Genetic Manipulation. — Centre for Research on Globalization Publishing, 2007.

Govind C.K., Gupta S.K. Failure of female baboons (Papio anubis) to conceive following immunization with recombinant non-human primate zona pellucida glycoprotein-B expressed in Esche­richia coli // Vaccine. — 2000. — V. 18. — P. 2970-2978.

Grimes S., Dov M., Vernon S. US2005112721 (A1) Chimeric peptide immunogens // Grimes S., Dov M., Vernon S. (США). Заявл. 05.05.2000; опубл. 26.05.2005.

Gupta J.C., Raina K., Talwar G.P. et al. Engineering, cloning and expression of genes encoding the multimeric luteini­sing-hormone-releasing-hormone linked to T-cell determinants in Esche­richia coli // Protein Express. Purif. — 2004. — V. 37. — P. 1-7.

Gupta S.K., Jethanandani P., Afzalpurkar A., Kaul R. et al. Prospects of zona pellucida glycoproteins as immunogens for contraceptive vaccine // Human Reproduction Update. — 1997. — V. 3, № 4. — P. 311-324.

Hans M.R., Berendina O.H. US20040166118. Peptide, immunogenic composition and vaccine or medical preparation, a method to immunize animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine // Hans M.R., Berendina O.H., Pepscan Systems B.V. (Нидерланды). Заявл. 07.06.1995; опубл. 26.08.2004.

Hilbe M., Jaros P., Ehrensperger F. et al. Histomorphological and immunohistochemical findings in testes, bulbourethral glands and brain of immunologically castrated male piglets // ­Schweiz. Arch. Tierheilkd. — 2006. — V. 148, № 11. — P. 599-608.

Hsu C.T., Ting C.Y., Ting C.J., Chen T.Y. et al. Vaccination against gonadotropin-releasing hormone (GnRH) using toxin receptor-binding domain-conjugated GnRH repeats // Cancer Res. — 2000. — V. 60. — P. 3701-3705.

Jeyakumar M., Moudgal N.R. Immunization of male rabbits with sheep luteal receptor to lutenizing hormone results in production of antibodies exhibiting hormone agonistic and antagonistic activities // J. Endocrinol. — 1996. — V. 150. — P. 431-443.

Jeyakumar M., Suresh R., Krishnamurthy H.N. et al. Changes in testicular function following specific deprivation of luteinizing hormone in the adult male rabbit // J. Endocrinol. — 1995. — V. 147. — P. 111-120.

Jones G.R., Sacco A.G., Subramanian M.G. et al. Histology of ovaries of female rabbits immunized with deglycosylated zona pellucida macromolecules of pigs // J. Reproduct. and Fertil. — 1992. — V. 95. — P. 513-525.

Jones W.R., Judd S.J., Ing R.M.Y. et al. Phase I clinical trial of a world health organisation birth control vaccine // The Lancet. — 1998. — V. 331, Is. 8598. — P. 1295-1298.

Kerr P.J., Jackson R.J., Robinson A.J. et al. Infertility in female rabbits (Oryctolagus cuniculus) alloimmunised with the rabbit zona pellucida protein ZPB either as a purified recombinant protein or expressed by recombinant myxoma virus // Biol. of Reproduct. — 1999. — V. 61. — P. 606-613.

Landsteiner K. Zur Kenntris der spezifisch auf blutko rperchen wirkenden sera // Zb. Bakt. — 1899. — V. 25. — P. 546-549.

Lemons A.R., Naz R.K. Contraceptive vaccines targeting factors involved in establishment of pregnancy // Am. J. Reprod. Immunol. — 2011. — V. 66, № 1. — P. 13-25.

Liskin L., Pile J.M., Quillan W.F. Vasectomy safe and simple // Popul. Rep. — 1983. — V. 4. — P. 61-100.

Luteinizing hormone. Электронный ресурс: http://en.wikipedia.org/wiki/Luteinizing_hormone.

Malthusianism. Электронный ресурс http://en.wikipedia.org/wiki/Malthusianism#Modern_Malthusianism.

Martinez M.L., Harris J.D. Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen // J. Reprod. Fertil. — 2000. — V. 120. — P. 19-32.

Meloen R.H., Wensing C.J. EP0464124 (A1). A peptide, immunogenic composition and vaccine or medicinal preparation / Stichting Centr. Diergeneeskund (Нидерланды). Заявл. 23.03.1989; опубл. 08.01.1992.

Metchnikoff E. Etudes sur la resorption de cellule // Ann. Inst. Pasteur. — 1899. — V. 13. — P. 737-779.

Miller L.A., Fagerstone K.A., Wagner D.C. et al. Factors contributing to the success of a single-shot, multiyear PZP immunocontraceptive vaccine for white-tailed deer // Human-Wildlife Conflicts. — 2009. — V. 3, № 1. — P. 103-115.

Moudgal N.R., Ravindranath N., Aravindan G.R. et al. Anti-FSH antibody as a probe in determining the role of FSH in the maintenance of gonadal function in the primate / Еd. by Ro­senwaks Z., Spieler J.M. // Nonsteroidal Gonadal Factors: Physio­logical Roles and Possibilities in Contraceptive Development. — CONDRAD Program, 1988. — P. 249.

Moudgal N.R., Sairam M.R., Krishnamurthy H.N. et al. Immunization of male bonnet monkeys (M. radiata) with a recombinant FSH receptor preparation affects testicular function and fertility // Endocrinol. — 1997. — V. 138. — P. 3065-3068.

Moudgall N.R., Sheela Rani C.S. Advances in immunology of gonadotropins / Еd. by C.H. Li // Hormonal Proteins and Peptides. — New York: Academic Press, 1983. — P. 135.

Moudgall N.R., Jeyakumar M., Krishnamurthy H.N. et al. Development of male contraceptive vaccine — a perspective // Human Reproduction Update. — 1997. — V. 3, № 4. — P. 335-346.

Murthy G.S., Srilatha N.S. Mapping of assembled epitope with microgram qualities of antigen: identification of an epitope at the receptor binding region of human follicle stimulating hormone // Curr. Sci. — 1996. — V. 70. — P. 1019-1022.

Murty G.S., Sheela Rani C.S., Moudgal N.R. et al. Effect of passive immunization with specific antiserum to FSH on the spermatogenic process and fertility of adult male bonnet monkeys (Macaca radiata) // J. Reprod. Fertil. — 1979. — V. 26. — P. 147-163.

Naz R.K. Antisperm contraceptive vaccines: where we are and where we are going? // Am. J. Reprod. Immunol. — 2011а. — V. 66. — P. 5-12.

Naz R.K. Contraceptive vaccines: success, status, and future perspective // Am. J. Reprod. Immunol. — 2011. — V. 66. — P. 2-4.

Naz R.K. Development of genetically engineered human sperm immunocontraceptives // J. Reprod. Immunol. — 2009. — V. 83, № 1–2. — P. 145-150.

Naz R.K. Immunocontraceptive effect of Izumo and enhancement by combination vaccination // Mol. Reprod. Dev. — 2008. — V. 75. — P. 336-344.

Naz R.K. Status of contraceptive vaccines // Am. J. Reprod. Immunol. — 2009. — V. 61, № 1. — P. 1-18.

Naz R.K., Chauhan S.C. Human sperm-specific peptide vaccine that causes long-term reversible contraception // Biol. Reproduce. — 2002. — V. 67. — P. 674-680.

Naz R.K., Guptan S.K., Gupta J.C. et al. Recent advances in contraceptive vaccine development: a mini-review // Hum. Reprod. — 2005. — V. 20, № 12. — Р. 3271-3283.

Nazari M., Mirshahi M., Mowla S.J. et al. Investigation in vitro expression of CatSper subfragment followed by production of polyclonal antibody: potential candidate for the next generation of non hormonal contraceptive // Cell. J. — 2012. — V. 14, № 3. — P. 215-24.

Nieschlag E. Reasons for abandoning immunization against FSH as an approach to male fertility regulation / Еd by Zatuchni G.I., Goldsmith A., Spieler J.M., Sciana J.J. // Male contraception: Advances and Future prospects. Professional Series on Fertility Regulation. — Philadelphia: Harper and Row, 1985. — P. 395.

Ohl D., Naz R.K. Infertility due to antisperm antibodies // J. Urol. — 1995. — V. 46. — P. 591-602.

Pau K.Y., Spie H.G. Neuroendocrine signals in the regulation of gonadotropin-releasing hormone secretion // Chin. J. Physiol. — 1997. — V. 31, № 40. — P. 181-196.

Potter A.A., Manns J.G. NZ333999 (A). GnRH-leukotoxin chimeric proteins for use in vaccines. — Univ. Saskatchewan (Канада). Заявл. 08.09.1996; опубл. 28.07.2000.

Rockefeller Foundation. Электронный ресурс http://en.wikipedia.org/wiki/Rockefeller_Foundation.

Roy B.M. WO 88/01176. Regulating animal reproduction // Bunge Australia. Заявл. 18.08.1986; опубл. 25.02.1988.

Sacco A.G., Pierce D.L., Subramanian M.G. et al. Ovaries remain functional in squirrel monkeys (Saimiri sciureus) immunized with porcine zona pellucida 55 000 macromolecule // Biol. Reproduct. — 1987. — V. 36. — P. 481-490.

Saenziturriaga L. US2012093846 (A1). Protein for the immunocastration for mammals // Saenziturriaga L. (Чили). Заявл. 15.04.2009; опубл. 19.04.2012.

Saxena B.B., Rathnam P. US2005/0032171. hCG-hLH receptor and hCG-hLH receptor-hCG complex as antigens, antibodies thereto and contraceptive vaccine // Cornell Res. Foundation Inc. (США). Заявл. 11.03.1993; опубл. 10.02.2005.

Schanbacher B.D. Effects of active immunization of the ram and bull against luteinizing hormone // Thenogenology. — 1985. — V. 24, № 1. — P. 59-71.

Sheela Rani C.S., Murty G.S.R.C., Moudgal N.R. Effect of chronic neutralization of endogenous FSH on testicular function in the adult male bonnet monkey — assessment using biochemical parameters // Int. J. Androl. — 1978. — V. 1. — P. 489-500.

Shirubaasa D.D., Maafui B.D., Meipurutofuto R.J. et al. JPH02113 (A). Agent and method for stimulating immune response to GNRH to immunologically make mammal sterile. — Univ. Saskatchewan (Канада). Заявл. 30.09.1987; опубл. 01.05.1990.

Skrlep M., Segula B., Zajec M. et al. Effect of immunocastration (Improvac®) in fattening pigs I: gro wth performance, reproductive organs and malodorous com pounds // Slov. Vet. Res. — 2010. — V. 47, № 2. — P. 57-64.

Spieler J. Development of immunological methods of fertility regulation // Bulletin of the World Health Organization. — 1987. — V. 65, № 6. — P. 779-783.

Srinath B.R., Wickings E.J., Witting C., Nieschlag E. Active immunization with follicle stimulating hormone for fertility control: a 4,5 year study in male rhesus monkeys // Fertil. Steril. — 1983. — V. 40. — P. 110-117.

Srivastava N., Santhanam R., Sheela P. et al. Evaluation of the immunocontraceptive potential of Escherichia coli-expressed recombinant dog ZP2 and ZP3 in a homologous animal model // Reproduction. — 2002. — V. 123. — P. 847-857.

Stevens V.C. Immunological approaches to fertility regulation // Bull. WHO. — 1978. — V. 56, № 2. — P. 179-192.

Stevens V.C., Cinader B., Powell J.E. et al. Preparation and formulation of a human chorionic gonadotropin antifertility vaccine: selection of adjuvant and vehicle // Am. J. Reprod. Immunol. — 1981. — V. 1. — P. 315-321.

Stevens V.C., Cinader B., Powell J.E. et al. Preparation and formulation of a human chorionic gonadotropin antifertility vaccine: selection of peptide immunogen // Am. J. Reprod. Immunol. — 1981. — V. 6. — P. 307-314.

Suresh R., Medhamurthy R., Moudgal N.R. Comparative studies on the effects of specific immunoneutralization of endogenous FSH or LH on testicular germ cell transformations in the adult bonnet monkey (Macaca radiata) // Am. J. Reprod. Immunol. — 1995. — V. 34. — P. 35-43.

Suresh R., Moudgal N.R. A role of nocturnal serum testosterone surge in regulating spermatogenesis in the adult non-human primate // Endocrine. — 1995. — V. 3. —

P. 487-492.

Talwar G.P. Contraception-immunological / Ed. by Delves P.J., Roitt I. // Encyclopaedia of Immunology. — 2nd ed. — London: Academic Press, 1997.

Talwar G.P. Vaccines for control of fertility and hormone-dependent cancers // Immunol. Cell Biol. — 1997. — V. 75. — P. 184-189.

Talwar G.P., Chaudhuri M. K., Jayashankar R. GB2228262. Antigenic derivative of GnRH. — Nat. Inst. Immunology (Индия). Заявл. 05.04.1989; опубл. 22.08.1990.

Talwar G.P., Sharma N.C., Dubey S.K. et al. Isoimmunization against human chorionic gonadotropin with conjugates of processed β-subunit of the hormone and tetanus toxoid // Proc. Natl. Acad. Sci. — 1976. — V. 73. — P. 218-222.

Talwar G.P., Singh O., Rao L.V. An improved immunogen for anti-human chorionic gonadotropin vaccine eliciting antibodies reactive with a conformation native to the hormone without crossreaction with human follicle stimulating hormone and human thyroid stimulating hormone // J. Reprod. Immunol. — 1988. — V. 14. —

P. 203-212.

Tollner T.L., Overstreet J.W., Branciforte D. et al. Immunization of female Cynomolgus macaques with a synthetic epitope of sperm-specific lactate dehydrogenase results in high antibody titres but does not reduce fertility // Mol. Reprod. Dev. — 2002. — V. 62. — P. 257-264.

Upadhyay S.N., Thillaikoothan P., Bamezai A. et al. Role of adjuvants in inhibitory influence of immunization with porcine zona pellucida antigen (ZP-3) on ovarian folliculogenesis in bonnet monkeys: a morphological Study // Biology of Reproduction. — 1989. — V. 41. — P. 665-673.

Urbanski H. Differential roles of GnRH-I and GnRH-II neurons in the control of the primate reproductive axis // Front. Endocrin. — 2012. — V. 3. — Article 20 (doi: 10.3389/fendo.2012.00020).

Wassarman P.M. Zona pellucida glycoproteins // The Jour. Biol. Hem. — 2008. — V. 283, № 36. — P. 24285-24289.

Yousafzai S. Pakistan: Mullahs and Militants Keep Polio Alive: электронный ресурс http://www.thedailybeast.com/articles/2012/12/19/pakistan-mullahs-and-militants-keep-polio-alive.html#url = /articles/2012/12/19/pakistan-mullahs-and-militants-keep-polio-alive.html.

Zona pellucida. Электронный ресурс http://ru.wikipedia.org/wiki/Zona_pellucida.




DOI: https://doi.org/10.22141/2312-413x.1.02.2014.82298

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