Modeling the Severity and Clinical Course of Rotavirus Diarrhea in Children

Yu.P. Kharchenko, I.V. Yurchenko, S.A. Yeryomenko, S.V. Kashintsev, A.A. Pitel

Abstract


We observed 3607 children aged from 9 days to 5 years with a diagnosis of acute gastroenteritis and acute gastroenterocolitis. Diarrheal syndrome was observed in 97.4 % of cases, vomiting — in 87.2 %, catarrhal phenomena — in 64.8 %. Diseases in children are caused by 5 major genotypes of rotavirus (G1R8, G2R4, G3R8, G4R8, G9R8). Clinical manifestations of rotavirus infection are closely correlated with leukogram, with erythrocyte sedimentation rate and the severity of metabolic acidosis. The greatest duration of diarrhea was observed in patients in whom rotavirus gastroenteritis was caused by a strain of genotype G1P8 (more common in children older than 2 years (t = 3.4; p < 0.01)).
A scheme has been developed to predict the course of rotavirus gastroenteritis, including the presence of mixed infection, to determine the severity of the pathological process by specially developed scale.


Keywords


children; rotavirus gastroenteritis; prediction of severity

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DOI: https://doi.org/10.22141/2312-413x.2.03.2014.82326

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