Diagnostic Value of Immunological Markers of the Inflammatory Response of the Body in Verifying the Bacterial Origin of Febrile Episodes of Bronchial Asthma in Infants and Preschool Children
The aim of research was to study the diagnostic value of some clinical and immunological tests in the verification of bacterial and/or viral infection in the course of febrile episodes of bronchial asthma exacerbations in children of early age. On the base of allergological department of Chernivtsi Regional Children’s Hospital by the method of simple random sampling there have been examined 104 child patients with bronchial asthma who were admitted to the hospital because of asthma exacerbation associated with fever, and of which were formed two groups of clinical observation. The conducted analysis of clinical and laboratory data in children with bacterial and viral febrile bronchial asthma attacks has been suggested that such patients more likely had higher level of immunological indices of inflammatory reactions, which are mostly characterized by increased content of serum interleukin-8 over 50.0 pg/ml (52.9 %) and serum C-reactive protein concentration more than 50.0 mg/l (43.1 %).
Full Text:PDF (Українська)
Subbarаo P. Asthma: epidemiology, etiology and risk factors / P. Subbarаo, P.J. Mandhane, M.R. Sears // Canad. Med. Associat. J. — 2009. — Vol. 181, № 9. — P. 181-190.
Friedlander S.L. Viral infection, cytokine dysregulation and the origins of childhood asthma and allergic diseases / S.L. Friedlander, D.J. Jackson, R.E. Gangnon // Pediatr. Infеct. Dis. J. — 2005. — Vol. 24 (suppl.). — P. 170-176.
Sutherland E.R. Asthma and atypical bacterial infection / E.R. Sutherland, R.J. Martin // Chest. — 2007. — Vol. 132. — P. 1962-1966.
Thorburn K. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis / K. Thorburn, S. Harigopal, V. Reddy // Thorax. — 2006. — Vol. 61. — P. 611-615.
Mills J.D. Chlamydia pneumoniae serological status is not associated with asthma in children or young adults / J.D. Mills, J.A. Lindeman // Int. J. Epidemiol. — 2000. — Vol. 29. — P. 280-284.
Korppi M. Chlamydia pneumoniae and newly diagnosed asthma: a case-control study in 1 to 6-year-old children / M. Korppi, M. Paldanius, A. Hyvarinen // Respirology. — 2004. — Vol. 9. — P. 255-259.
Jahnz-Rozyk K. Atypical infection of the respiratory tract and bronchial asthma / K. Jahnz-Rozyk, T. Targowski // Pol. Merkur. Lekarski. — 2007. — Vol. 137. — P. 325-327.
Wark P.A.B. Asthma exacerbations. 3: Pathogenesis / P.A.B. Wark, P.G. Gibson // Thorax. — 2006. — Vol. 61. — P. 909-915.
Busse W.W. The precipitation of asthma by upper respiratory infections // Chest. — 2007. — Vol. 87. — P. 44-48.
Walter M.J. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response / M.J. Walter, J.D. Morton, N. Kajiwara // J. Clin. Invest. — 2002. — Vol. 202. — P. 165-175.
Hussain I. Evidence for the Transmissibility of Atopy. Hypothesis / I. Hussain, J. Smith // Chest. — 2003. — Vol. 124. — P. 1968-1974.
Esposito S. Asthma in children: are Chlamydia or Mycoplasma involved? / S. Esposito, N. Principi // Pediatr. Drugs. — 2001. — Vol. 3. — P. 159-168.
Copyright (c) 2016 ACTUAL INFECTOLOGY
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2018