Nature of Hepatitis in Infectious Mononucleosis in Patients of Different Age with Typical and Subclinical Signs of the Disease

A.R. Shaapuni, A.L. Mkhitaryan


Enlarged liver and spleen — one of the cardinal syndromes of infectious mononucleosis (IM), so figuring out the frequency, nature and severity of hepatitis in children and adults with IM with typical and subclinical manifestations of peripheral lymphadenopathy is relevant.
The study was carried out in 135 patients with IM of different age: from 1 to 7 years — 80 persons; from 7 to 18 years — 25 and 18 years and older — 30. All patients underwent the general study of the blood, serologic examination for detection of IgM antibodies to Epstein — Barr virus (EBV) by ELISA and/or polymerase chain reaction for the presence of EBV and cytomegalovirus DNA in peripheral blood, biochemical blood tests (to determine the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), levels of total bilirubin and its fractions, alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT)), identification of markers of viral hepatitis, ultrasound examination of internal organs.
It is shown that among patients with IM hepatomegaly is most significant in children younger than 7 years. Mild jaundice associated with moderate increase in both fractions of bilirubin, occurs in about one of ten patients and was more common in children up to 7 years. At the same time, an increase of transaminases activity was observed significantly more frequently in adult patients compared to patients with children and was detected with equal frequency in patients with typical and atypical manifestations of lymphadenopathy.
Prevailing mild increased activity of enzymes (ALT, AST, GGT, ALP), a small violation of bilirubin metabolism indicate some transient disturbances in the functional capacity of the liver in IM, caused by concomitant reversible acute hepatitis of low or moderate activity.


Булдык Е.А., Дмитраченко Т.И. Функция печени у больных инфекционным мононуклеозом // 4-й Конгресс педиатров-инфекционистов России «Актуальные вопросы инфекционной патологии и вакцинопрофилактики у детей». — М., 2005. — С. 41.

Гаспарян М.О., Слученкова Л.Д., Клиника и течение инфекционного мононуклеоза у детей раннего возраста // Педиатрия. — 1975. — № 1. — С. 63-66.

Живица Л.В., Пономаренко Г.Ф., Преденина В.А. Особенности течения инфекционного мононуклеоза у детей и взрослых // Клиническая медицина. — 1987. — Т. 165. № 10. — С. 121-123.

Кудин А.П. Эта «безобидная» вирус Эпштейна — Барр инфекция. Часть 2. Острая ВЭБ-инфекция: эпидемиология, клиника, диагностика, лечение // Медицинские новости. — 2006. — Т. 1, № 8. — С. 25-31.

Кучеренко Н.П., Медведева В.В., Тычинская Т.Л. Особенности клинического течения инфекционного мононуклеоза у детей на современном этапе // Медико-социальные проблемы семьи. — 2012. — Т. 17, № 3–4.

Несвит У.Ю. Нарушения микрофлоры кишечника у детей с инфекционным мононуклеозом: Автореф. дис… канд. мед. наук: 14.00.09. — Ставрополь, 2009.

Нисевич Н.И., Казарин B.C., Гаспарян М.О., Гусева Л.Н. К вопросу о классификации и клинических формах инфекционного мононуклеоза у детей // Педиатрия. — 1974. — № 8. — С. 3-8.

Carbonero C., Torronteras S.R., Cintado B.C. Infectious mononucleosis: study on hospitalized children // An. Esp. Pediat. — 1999. — 51, 6. — 664-666.

Feigin R.D., Cherry J.D. Pediatric infection diseases. — 1992. — Ch. 1447. — P. 1547-1557.

Stephen R., Godshall M., Jeffrey Т., Kirchner D.O. Infectious mononucleosis. Complexities of a common syndrome // Postgrad. Medicine. — 2000. — Vol. 107, № 7. — P. 320-329.

Yuge A., Kinoshita E., Moriuchi M. et al. Persistent hepatitis associated with chronic active Epstein-Barr virus infection // Pediat. Infect. Dis. J. — 2004. — 23, 1. — 74-76.



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