Modern Aspects of Pulmonary Mycobacteriosis (Analytical Review)

L.D. Todoriko, O.S. Shevchenko


The analysis of available scientific literature sources on the modern aspects of pulmonary mycobacteriosis is described in the article. The incidence of mycobacteriosis is 2.3 per 100 thousand of population, and pulmonary manifestation is observed in 94 % of cases. Analytical review has shown that in the clinic of internal and infectious diseases, there are increasingly diagnosed different variants of mycobacteriosis that indicates an increase of atypical mycobacteria role in the formation of respiratory patho­logy in humans. It is ascertained that microbiological study of the basic characteristics of nontuberculosis mycobacteria are not paid enough attention. It was concluded that most often mycobacterioses have tuberculosis-like clinical pattern and are difficultly diagnosed, often form mixed infection with tuberculosis; atypical mycobacteria are characterized by a wide range of resistance and potential pathogenicity for humans and animals. Risk factors of pulmonary mycobacteriosis, variants of clinical course, modern methods of the diagnosis and treatment approaches depending on the course are analyzed. It is shown that treatment of pulmonary mycobacteriosis is long and lasts for 12 months after receiving a negative sputum culture (conversion often takes place in 3–6 months).


mycobacteriosis; nontuberculous mycobacteria; classification; diagnosis; treatment


Ljul'chuk MG. Studying the causes of inefficiency virological ART early in terms of HIV-infected patients. Aktual'naja infektologija. 2015; 1 (6): 58-66. (In Ukrainian).

Makarova MV. Vydelenie i identifikacija netuberkuljoznyh mikobakterij u pacientov ftiziatricheskih uchrezhdenij. [Isolation and identification of mycobacteria in TB nontubercular institutions patients]. Avtoreferat dissertacii. Moskva: 2010. 48 р. (in Russian).

Griffith D., Reyn C., Bloom A., Elliott. Overview of nontuberculous mycobacterial infections in HIV-negative patients. Am J Respir Crit Care Med. 2011; 17: 37-41.

Novozhy`lova IO. Results of clinical observation of patients that emit no tuberculous mycobacteria. Ukr. pul`mon. zh. 2003; 4: 30-31. (In Ukrainian).

Yavors`ka GV. Morphological and cultural and physiological and biochemical properties of atypical mycobacteria. Mikrobiologichny`j zhurnal. 2009; 71(4): 27-34. (In Ukrainian).

Nakaz MOZ Ukrayiny` 887 vid 22.12.2015. Pro zatverdzhennya zmin do Klinichnogo protokolu anty`retrovirusnoyi terapiyi VIL-infekciyi u dorosly`x ta pidlitkiv. [On approval of amendments to the Clinical Protocol antiretroviral treatment of HIV infection in adults and adolescents] . (In Ukrainian).

Todoriko LD, Pidverbecz`ka OV. State microbiota colon pulmonary tuberculosis based on spectral sensitivity of Mycobacterium tuberculosis and komorbidnistyu in patients with HIV / TB. Tuberkul`oz, legenevi xvoroby`, VIL-infekciya. 2015; 3: 39-44. (In Ukrainian).

Todoriko LD, Podverbeckaja EV. Clinical analysis of lethal cases of HIV-associated tuberculosis. In: Proceedings of the international scientific-practical conference "HIV-associated TB: epidemiological, clinical and social aspects. Grodno. 2015 October 29-30; Grodno. Belorussia. Grodno; 2015: 91-94. (in Russian).

Ballarino GJ, Olivier KN, Claypool RJ. Pulmonary nontuberculous mycobacterial infections: antibiotic treatment and associated. Respir. Med. 2009; 103(10): 1448-1455.

Starkova DA. Actual human pathogen mycobacteriosis. – Infekcija i immunitet. 2013; 3(1): 7-14. (in Russian).

Bodle EE, Cunningham JA, Della-Latta P. Epidemiology of Nontuberculous Mycobacteria in Patients without HIV Infection. Emerging Infectious Diseases. 2008; 14(3): 390-396.

Griffith DE. Aksamit T, Brown-Elliott BA. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. American journal of respiratory and critical care medicine. 2007; 175:367-416.

Centre for Disease Control. Department of Health Northern Territory. Guidelines for the control of nontuberculous mycobacteria in the Northern Territory. Darwin: Centre for Disease Control, Northern Territory Government; 2002.

Nontuberculosis mycobacteria (NTM). Guidelines for health professionals in the Nothern Territory; 2014.125 р.

Griffith DE, Aksamit T, Brown-Elliott BA. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007; l(175): 367-416.

Ryu YJ, Koh WJ, Daley CL. Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease: Clinicians. Tuberc Respir Dis (Seoul). 2016; 79 (2): 74-84.

Wallace RJ, Glassroth CJ, Griffith DE. Supplement: American Thoracic Society Diagnosis and Treatment of Disease Caused by Nontuberculous Mycobacteria. American Journal of Respiratory and Critical Care Medicine. 1997; 156(2): 2.

Tran QT, Han XY. Subspecies Identification and Significance of 257 Clinical Strains of Mycabacterium avium. Journal of Clinical Mycrobiology. 2014; 52(4): 1201-1206.

Horsburgh CR. Epidemiology of Mycobacterium avium complex. Mycobacterium avium сomplex infection: Progress in Research and Treatment. New York, NY: Marcel Dekker.1996: 1-22.

Radomski N, Thibault VC, Karoui C. Determination of Genotyping Diversity of Mycobacterium avium Subspecies from Human and Animal Origins by Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat and IS1311 Restriction Fragment Length Polymorphism Typing Methods. Journal of Clinical Microbiology. 2010; 48(4): 1026-1034.

Cayrou C, Turenne C, Behr MA. Genotyping of Mycobacterium avium complex organisms using multispacer sequence typing. Microbiology. 2010; 156: 687-694.

Daley CL, Griffith DE. Pulmonary non-tuberculous mycobacterial infections. Int. J. Tuberc. Lung Dis. 2010; 14(6): 665-671.

Hog WJ, Kwon OJ, Lee KS. Nontuberculous Mycobacterial Pulmonary Diseases in Immunocompetent patients. Kprean J Radiol. 2002; 3(3): 145-157.

Jun HJ, Lee NY, Kim J. Successful treatment of Mycobacterium celatum pulmonary disease in an immunocompetent patient using antimicobacterial chemotherapy and combined pulmonary resection. Yonsei Med. J. 2010; 51(6): 980-983.

Sakatani M, Nakajima Y. Treatment of non-tuberculous pulmonary mycobacteriosis. National Hospital Organization Kinki-chuo Chest Medical Center, 1180, Nagasone-cho, Sakai-shi, Osaka 591-8555, Japan. 2006; 81(1): 35-50.

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