Impact of drug resistance on the tuberculosis treatment outcome

Authors

  • E. Lesnic Nicolae Testemiţanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
  • A. Niguleanu Nicolae Testemiţanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
  • A. Ustian Nicolae Testemiţanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
  • L. Todoriko Higher State Education Institution of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine

DOI:

https://doi.org/10.22141/2312-413x.5.2.2017.105319

Keywords:

multidrug-resistance, multidrug-resistant tuberculosis, risk factors

Abstract

Background. The standard treatment of a new case of multidrug-resistant tuberculosis (MDR-TB) according to WHO recommendations in the Republic of Moldova is performed since 2005 showing a low treatment succes. Actually the treatment success rate increased due to excluding of MDR-TB patients from the general cohort. The major rate of patients with low outcome is represented by the failed and lost to follow-up cases. The purpose of the study was to assess the impact of multidrug-resiatnce and MDR-TB on the tuberculosis treatment outcome. Materials and methods. A retrospective selective, descriptive study targeting social, demographic, economic and epidemiological peculiarities, case-management, diagnostic radiological aspects and microbiological characteristics of 187 patients with pulmonary tuberculosis registered during 2013–2015 distributed in two groups: 1st group (61 patients) with established multidrug-resistant strains using conventional cultural methods and the 2nd group (126 patients) with MDR-TB. Results. Multidrug-resistance was established more frequently in new cases and MDR-TB in two thirds of retreated patients. No difference was identified in gender and age distribution, social, economical, educational characteristics; case-management assessment identified a similar proportion of patients revealed by general practitioners and specialists, with low rate of screened high risk groups. All patients from the multidrug-resistant group began the standard treatment for drug-responsiveness tuberculosis before drug susceptibility testing and one third of MDR-TB group was treated from the onset with the DOTS-Plus regimen. Highest success rate was identified in the new-case subgroups of both groups and higher rate of died patients was determined in the retreated subgroups. Such a low rate of patients aggrevates the resistance. Conclusions. Early diagnosis, drug responsiveness testing and raising awareness among about treatment compliance will improve disease outcome.

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References

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Published

2022-01-25

How to Cite

Lesnic, E., Niguleanu, A., Ustian, A., & Todoriko, L. (2022). Impact of drug resistance on the tuberculosis treatment outcome. ACTUAL INFECTOLOGY, 5(2), 78–84. https://doi.org/10.22141/2312-413x.5.2.2017.105319

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Section

Original Researches