Modern etiopathogenetic and clinical features of rotavirus infection in children

Authors

  • M.N. Garas Higher State Educational Institution of Ukraine “Bukovinan State Medical University”, Chernivtsi, Ukraine
  • U.I. Marusyk Higher State Educational Institution of Ukraine “Bukovinan State Medical University”, Chernivtsi, Ukraine

DOI:

https://doi.org/10.22141/2312-413x.7.1.2019.159223

Keywords:

rotavirus infection, gastroenteritis, diarrhea, children

Abstract

The paper shows the leading etiological role of rotavirus infection among the causes of acute gastroenteritis and secretory diarrhea in childhood. It describes the contribution of rotavirus in the structure of nosocomial gastrointestinal infections. In a temperate climate, the pathogen is characterized by winter seasonality and a certain age dependence (mostly at an early age). The typical clinical features of rotavirus infection are a combination of respiratory and gastrointestinal manifestations in the form of respiratory catarrh and acute gastroenteritis. In recent years, the role of rotavirus in the development of extraintestinal cerebral symptoms (meningoencephalitis, seizures, myositis, and poliomyelitis-like illnesses) has been proved.

Downloads

Download data is not yet available.

References

Gorelov AV, Ploskireva AA, Usenko DV. Modern approaches to pathogenetic therapy for acute enteric infections in children. Infectious Diseases. 2013;11(1):87-92. (in Russian).

Smijan OI, Bynda TP, Smijan KO. Modern view on the clinical picture of acute intestinal infections in children. Visnyk Sums'kogo derzhavnogo universytetu. Medycyna. 2012;(2):142-152. (in Ukrainian).

Maly VP, editor. Virusnye diarei u detei i vzroslykh [Viral diarrhea in children and adults]. SPb: Taktik-studio; 2011. 104 p. (in Russian).

Cortese MM, Parashar UD; Centers for Disease Control and Prevention (CDC). Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2009 Feb 6;58(RR-2):1-25.

Chernyshova LI, Kharchenko YuP, Yurchenko IV, et al. Problem of rotavirus diarrhea in children. Sovremennaya pediatriya. 2011;(35):31-34. (in Russian).

Kramarev SA, Zakordonets LV. Rotavirus infection: epidemiology and prevention. Zdorovʹe rebenka. 2011;(28):53-55. (in Russian).

Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):132-52. doi: 10.1097/MPG.0000000000000375.

Akoua-Koffi C, Asse Kouadio V, Yao Atteby JJ. Hospital-based surveillance of rotavirus gastroenteritis among children under 5 years of age in the Republic of Ivory Coast: a cross-sectional study. BMJ Open. 2014;4(1):e003269. doi: 10.1136/bmjopen-2013-003269.

Solovyov SO. Mathematical modeling as a modern tool of projecting the efficacy of rotavirus vaccines. Medical Informatics and Engineering. 2011;(2):59-63. doi: 10.11603/mie.1996-1960.2011.2.43.

Koloskova OK, editor. Dytjachi infekcijni hvoroby v moduljah: navchal'nyj posibnyk [Pediatric infectious diseases in modules: a tutorial]. Chernivtsi: Misto; 2013. 196 p. (in Ukrainian).

Kramarev SO, Nadraga OB, Pypa LV, et al., authors; Kramarev SO, Nadraga OB, editors. Infekcijni hvoroby v ditej: pidruchnyk [Infectious diseases in children: a textbook]. Kyiv: VSV Medycyna; 2010. 392 p. (in Ukrainian).

Chow CM, Leung AK, Hon KL. Acute gastroenteritis: from guidelines to real life. Clin Exp Gastroenterol. 2010;3:97-112.

Ball JM, Mitchell DM, Gibbons TF, Parr RD. Rotavirus NSP4: a multifunctional viral enterotoxin. Viral Immunol. 2005;18(1):27-40. doi: 10.1089/vim.2005.18.27.

Lorrot M, Benhamadouche-Casari H, Vasseur M. Mechanisms of net chloride secretion during rotavirus diarrhea in young rabbits: do intestinal villi secrete chloride? Cell Physiol Biochem. 2006;18(1-3):103-12. doi: 10.1159/000095174.

Tafazoli F, Zeng CQ, Estes MK, Magnusson KE, Svensson L. NSP4 enterotoxin of rotavirus induces paracellular leakage in polarized epithelial cells. J Virol. 2001;75(3):1540-6. doi: 10.1128/JVI.75.3.1540-1546.2001.

Esona MD, Buteau J, Lucien MA, et al. Rotavirus group A genotypes detected through diarrheal disease surveillance in Haiti, 2012. Am J Trop Med Hyg. 2015 Jul;93(1):54-6. doi: 10.4269/ajtmh.14-0403.

Beau I, Cotte-Laffitte J, Géniteau-Legendre M, Estes MK, Servin AL. An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells. Cell Microbiol. 2007 Sep;9(9):2254-66. doi: 10.1111/j.1462-5822.2007.00956.x.

Maly VP, Romantsov MG. Viral diarrhea. Infectious Diseases. 2013;(4):5-16. doi: 10.11603/1681-2727.2013.4.2220. (in Ukrainian).

Kramarev SO, Vygovskaia OV, Bol'shakova LA, Savina EV, Grinevich AI. Viral diarrhea in children: features of the clinical picture, diagnosis, modern approaches to therapy. Dytjachyj likar. 2014;(32-33):3-10. (in Russian).

Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014 Jul;59(1):132-52. doi: 10.1097/MPG.0000000000000375.

Cox E, Christenson JC. Rotavirus. Pediatr Rev. 2012 Oct;33(10):439-45; quiz 446-7. doi: 10.1542/pir.33-10-439.

Pypa LV, Len'ga VR, Piddubna OV. Rotavirus infection in children: clinical and diagnostic features. Laboratorna diagnostyka. 2008;(2):31-38. (in Ukrainian).

Dzjublyk IV, Obertyns'ka OV, Kostenko IG. Detection of rotavirus infection in children in the winter - spring 2006-2007. Racionalʹna farmakoterapia. 2008;(3):1-4. (in Ukrainian).

Vasil'ev BIa, Vasil'eva RT, Lobzin IuV. Ostrye kishechnye zabolevaniia. Rotavirusy i rotavirusnaia infektsiia [Acute intestinal diseases. Rotaviruses and rotavirus infection]. SPb: Lan'; 2000. 272 p. (in Russian).

Chernyshova LI. New protection against rotavirus infection in young children. Pediatrija, akusherstvo ta ginekologija. 2001;(2):51-55. (in Ukrainian).

Shiihara T, Watanabe M, Honma A, et al. Rotavirus associated acute encephalitis/encephalopathy and concurrent cerebellitis: report of two cases. Brain Dev. 2007 Nov;29(10):670-3. doi: 10.1016/j.braindev.2007.04.005.

Dickey M, Jamison L, Michaud L, Care M, Bernstein DI, Staat MA. Rotavirus meningoencephalitis in a previously healthy child and a review of the literature. Pediatr Infect Dis J. 2009 Apr;28(4):318-21. doi: 10.1097/INF.0b013e31818ddbe9.

Furuya Y, Katayama T, Miyahara K, Kobayashi A, Funabiki T. Detection of the rotavirus A genome from the cerebrospinal fluid of a gastroenteritis patient: a case report. Jpn J Infect Dis. 2007 May;60(2-3):148-9.

Published

2021-09-28

How to Cite

Garas, M., & Marusyk, U. (2021). Modern etiopathogenetic and clinical features of rotavirus infection in children. ACTUAL INFECTOLOGY, 7(1), 13–16. https://doi.org/10.22141/2312-413x.7.1.2019.159223

Issue

Section

Original Researches

Most read articles by the same author(s)

1 2 > >>